CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD24
Family Name Beta adrenergic receptor ligand monosubstituted indole derivative Pindolol family
No. of Seeds 14 No. of Other Members 475
Family Centroid CFAMM00006824 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Beta adrenergic receptor ligand monosubstituted indole derivative Pindolol Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Apricoxib family 8 77
Indeglitazar family 3 39
Grt 6005/06 family 4 22
PF-02545920 family 16 140
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Tyrosine kinase Inhibitor PKI166 Family 17 198
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Progesterone receptor Ligand PF-02367982 Family 2 8
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase and Cholinesterase Inhibitor 1,4-di(berbe... 5 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1A ligand (2S)-1-[(3S,4R)-3-(1,3-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 36 18
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Sodium-dependent serotonin transporter inhibitor 4-[(2S)-2-hyd... 4 0
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 5
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Transient receptor potential cation channel subfamily V member... 1 5
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Beta-3 adrenergic receptor ligand 3-[2-[[(2R)-2-(3-chloropheny... 1 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Sodium-dependent serotonin transporter inhibitor (2S)-1-[(2S,4... 7 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 4
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Glucagon receptor ligand SureCN2647807 family 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04UHB... 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Urokinase-type plasminogen activator and Tissue-type plasminog... 1 4
Nischarin inhibitor SureCN7810370 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Cytochrome P450 2D6 inhibitor AGN-PC-075CGG family 1 2
Transient receptor potential cation channel subfamily V member... 3 2
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Beta-3 adrenergic receptor ligand SureCN7133396 family 1 0
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 2 2
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Histamine H1 receptor and Histamine H2 receptor ligand AGN-PC-... 1 1
Sugar Acids and Derivatives Metabolite 6-Hydroxy-5-methoxyindo... 3 1
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
Putative NP ZINC20112899 Family 6 0
Putative NP ZINC40309500 Family 4 0
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium NP ZINC02119030... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00007071 DAP000135 Approved Drug Carvedilol
CFAMM00006824 DAP000025 Approved Drug Pindolol
CFAMM00006751 CHEMBL236514 Bioactive (2S)-1-(1-adamantylamino)-3-(1H-indol-4-yloxy)propan-2-ol
CFAMM00006584 CHEMBL396185 Bioactive 2-Propanol, 1-(cyclohexylamino)-3-(1H-indol-4-yloxy)-
CFAMM00006756 CHEMBL237572 Bioactive AGN-PC-039BXE
CFAMM00007001 CHEMBL1082501 Bioactive AGN-PC-07ZG2Y
CFAMM00007032 CHEMBL393648 Bioactive SureCN7289830
CFAMM00006909 DNC004894 Investigative Drug BUCINDOLOL
CFAMM00006624 DNC007817 Investigative Drug 4-(1H-indol-4-yloxy)-1-(isopropylamino)butan-2-ol
CFAMM00006783 DNC009288 Investigative Drug SDZ-201106
CFAMM00007067 DNC000387 Investigative Drug Carazolol
CFAMM00007053 DNC001652 Investigative Drug Cyanopindolol
CFAMM00006571 DNC003798 Investigative Drug Benzyl-[2-(1H-indol-4-yloxy)-ethyl]-amine
CFAMM00006587 DNC012635 Investigative Drug 1-(1H-Indol-4-yloxy)-3-phenethylamino-propan-2-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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