CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD244
Family Name Alpha-1D adrenergic receptor Ligand Terazosin Family
No. of Seeds 28 No. of Other Members 638
Family Centroid CFAMM00043233 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Alpha-1D adrenergic receptor Ligand Terazosin Superfamily
Class Class 211

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 6,7-dimethoxy-2-[4-[(5-oxi... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Alpha-1A adrenergic receptor ligand 4-[4-(4-amino-6,7-dimethox... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 3 1
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Aurora kinase A inhibitor SureCN4289024 family 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[(5-fl... 3 2
Transient receptor potential cation channel subfamily V member... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
5-hydroxytryptamine receptor 3A and Histamine H4 receptor liga... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 4 3
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Vascular endothelial growth factor receptor 1 and Vascular end... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00043233 DAP000371 Approved Drug Terazosin
CFAMM00043178 DAP000381 Approved Drug Doxazosin
CFAMM00043232 DAP000370 Approved Drug Alfuzosin
CFAMM00043449 DAP000300 Approved Drug Prazosin
CFAMM00043407 CHEMBL162538 Bioactive [(3R)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3-diethylpiperazin-1-yl]-(furan-2-yl)methanone
CFAMM00043324 CHEMBL154624 Bioactive AGN-PC-00PT39
CFAMM00043317 CHEMBL155264 Bioactive AGN-PC-00PT3A
CFAMM00043406 CHEMBL159440 Bioactive [(3R)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3-dimethylpiperazin-1-yl]-(furan-2-yl)methanone
CFAMM00043391 CHEMBL154212 Bioactive AGN-PC-00PT30
CFAMM00042947 CHEMBL266317 Bioactive 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-N-(2-phenoxyethyl)piperidine-4-carboxamide
CFAMM00043334 CHEMBL343283 Bioactive SureCN7823280
CFAMM00043438 CHEMBL558890 Bioactive [(4aS,8aR)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
CFAMM00042910 CHEMBL262745 Bioactive AGN-PC-00NPMW
CFAMM00042889 CHEMBL346693 Bioactive AGN-PC-00NPMV
CFAMM00043060 CHEMBL1558 Bioactive Prazosin hydrochloride
CFAMM00042826 CHEMBL564481 Bioactive CYCLODOXAZOSIN
CFAMM00043346 CHEMBL160908 Bioactive [(3R)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazin-1-yl]-(furan-2-yl)methanone
CFAMM00042833 CHEMBL97698 Bioactive [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl](furan-2-yl)methanone
CFAMM00042798 CHEMBL424516 Bioactive AGN-PC-00PT3B
CFAMM00043229 CHEMBL159888 Bioactive AGN-PC-00F7Y1
CFAMM00043310 CHEMBL351897 Bioactive [(4aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone
CFAMM00043400 CHEMBL561851 Bioactive N-[6-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]hexyl]-N-methyl-2,3-dihydro-1,4-benzodioxine-3-carboxamide
CFAMM00043415 CHEMBL335731 Bioactive 1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-2-(2,6-dimethoxyphenoxy)ethanone
CFAMM00043429 CHEMBL430717 Bioactive SureCN5789541
CFAMM00043484 DCL000664 Clinical Trial Drug Xatral
CFAMM00043260 DNC000930 Investigative Drug Metazosin
CFAMM00042977 DNC000492 Investigative Drug Cyclazosin
CFAMM00042848 DNC001201 Investigative Drug REC2615

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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