CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD248
Family Name Beta-1 adrenergic receptor Ligand Esmolol Family
No. of Seeds 5 No. of Other Members 39
Family Centroid CFAMM00043718 Functional Category Approved Drug with Natural Product
Superfamily adrenergic receptor ligand Esmolol Metoprolol Superfamily
Class Class 149

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Renin Inhibitor Aliskiren Family 28 107
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Extracellular calcium-sensing receptor Ligand Ronacaleret Family 2 9
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Potassium voltage-gated channel subfamily H member 2 Ligand Al... 2 3
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Tyrosine-protein phosphatase non-receptor type 1 Ligand PNU177... 1 5
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Extracellular calcium-sensing receptor and Sodium-dependent no... 2 2
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Sodium-dependent serotonin transporter and Transporter inhibit... 2 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Neprilysin inhibitor SureCN389939 family 5 6
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 1 0
Pol polyprotein inhibitor MDL 74538 family 11 1
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 1 0
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Squalene synthase inhibitor [4-[3-(propan-2-ylamino)propoxy]ph... 1 3
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 3
Tyrosine-protein phosphatase non-receptor type 1 ligand FLUORO... 1 1
Toluenes Metabolite Metaxalone Family 1 0
2-[(E)-3-(2-methoxyphenyl)prop-2-enoyl]oxyethyl-methyl-propan-... 1 0
2-(5-methoxy-4,8,8-trimethyl-2-oxo-9,10-dihydropyrano[2,3-h]ch... 11 0
Putative NP ZINC00050501 Family 6 4
[(2S)-3-(4,8-dimethyl-2-oxochromen-7-yl)oxy-2-hydroxypropyl]-(... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00043718 DAP000304 Approved Drug Esmolol
CFAMM00043721 DAP000482 Approved Drug Atenolol
CFAMM00043702 CHEMBL31025 Bioactive methyl 3-[4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]propanoate
CFAMM00043701 CHEMBL30292 Bioactive methyl 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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