CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD249
Family Name Beta-1 adrenergic receptor Ligand Metoprolol Family
No. of Seeds 29 No. of Other Members 90
Family Centroid CFAMM00043871 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily adrenergic receptor ligand Esmolol Metoprolol Superfamily
Class Class 149

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Extracellular calcium-sensing receptor Ligand Ronacaleret Family 2 9
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
Substance-P receptor Ligand Ezlopitant Family 10 207
Alpha-2 adrenergic receptor Ligand Idazoxan Family 6 26
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
D(3) dopamine receptor Ligand U-99194A Family 7 33
Vernakalant family 1 1
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 Ligand Al... 2 3
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Beta-3 adrenergic receptor Ligand ZD7114 Family 1 4
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 1A Ligand Tertatolol Family 1 1
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Extracellular calcium-sensing receptor and Sodium-dependent no... 2 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 8
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Squalene synthase inhibitor 3-[4-[[(E)-ethylideneamino]oxymeth... 1 0
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Pol polyprotein inhibitor (4R,5S,6S,7R)-1,3-Dibenzyl-5,6-dihyd... 3 3
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 1 0
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Neuronal acetylcholine receptor subunit alpha-10 ligand (2S)-2... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Squalene synthase inhibitor [4-[3-(propan-2-ylamino)propoxy]ph... 1 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 5
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 0
Extracellular calcium-sensing receptor ligand SureCN4609584 fa... 7 8
Membrane primary amine oxidase inhibitor 2-hydrazinyl-1-(4-met... 1 2
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 1 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 3
Beta-lactamase inhibitor CHEMBL1566697 family 1 5
Cytochrome P450 2D6 and Sodium channel protein type 1 subunit ... 1 1
2-[(E)-3-(2-methoxyphenyl)prop-2-enoyl]oxyethyl-methyl-propan-... 1 0
2-(5-methoxy-4,8,8-trimethyl-2-oxo-9,10-dihydropyrano[2,3-h]ch... 11 0
[(2S)-3-(4,8-dimethyl-2-oxochromen-7-yl)oxy-2-hydroxypropyl]-(... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00043738 DAP000941 Approved Drug Alprenolol
CFAMM00043786 DAP001396 Approved Drug Levobetaxolol
CFAMM00043865 DAP000305 Approved Drug Betaxolol
CFAMM00043871 DAP000481 Approved Drug Metoprolol
CFAMM00043824 DAP000938 Approved Drug Penbutolol
CFAMM00043870 DAP000483 Approved Drug Bisoprolol
CFAMM00043854 CHEMBL31021 Bioactive 1-(2-methylphenoxy)-3-(2-methylpropylamino)propan-2-ol
CFAMM00043869 CHEMBL67151 Bioactive 1-(4-methylphenoxy)-3-(propan-2-ylamino)propan-2-ol
CFAMM00043768 CHEMBL43405 Bioactive Flusoxolol
CFAMM00043803 CHEMBL7250 Bioactive 1-[4-(2-cyclohexyloxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
CFAMM00043873 CHEMBL1691 Bioactive Betaxolol hydrochloride
CFAMM00043818 CHEMBL31811 Bioactive 1-[(2-methylpropyl)amino]-3-phenoxypropan-2-ol
CFAMM00043776 CHEMBL544190 Bioactive 1-[4-[2-(cyclobutylmethoxy)ethyl]phenoxy]-3-(cyclopropylamino)propan-2-ol;hydrochloride
CFAMM00043857 CHEMBL1159892 Bioactive Procinolol
CFAMM00043775 CHEMBL252319 Bioactive SureCN79268
CFAMM00043783 CHEMBL542536 Bioactive 1-[4-(2-cyclopentyloxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride
CFAMM00043840 CHEMBL31529 Bioactive ethyl 3-[[2-hydroxy-3-(2-methylphenoxy)propyl]amino]-3-methylbutanoate
CFAMM00043774 CHEMBL1159723 Bioactive DIHYDROALPRENOLOL
CFAMM00043864 CHEMBL267375 Bioactive 1-[4-(2-cyclopentyloxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
CFAMM00043855 CHEMBL6939 Bioactive BRN 5959963

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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