CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD252
Family Name C-C chemokine receptor type 5 Ligand Maraviroc Family
No. of Seeds 29 No. of Other Members 81
Family Centroid CFAMM00044373 Functional Category Approved Drug
Superfamily chemokine receptor ligand Maraviroc, Dipeptidyl peptidase inhibitor superSitagliptin family
Class Class 214

Cousin Family NamesSeedsMembers
Dipeptidyl peptidase 4 Inhibitor Sitagliptin Family 6 4
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-(3-methyl-5-... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 3ant family 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 2 0
C-C chemokine receptor type 5 ligand 3-(4-methylphenyl)-1-[3-[... 2 12
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1
Dipeptidyl peptidase 4 and Seprase inhibitor CHEBI:39959 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00044373 DAP000308 Approved Drug Maraviroc
CFAMM00044413 CHEMBL558779 Bioactive (3R)-3-amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
CFAMM00044360 CHEMBL540888 Bioactive (3R)-3-amino-1-[8-[(2-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
CFAMM00044391 CHEMBL401304 Bioactive (3R)-3-amino-1-[(8R)-8-[(4-fluorophenyl)methyl]-2-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
CFAMM00044340 CHEMBL489513 Bioactive 3,3-difluoro-N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]cyclobutane-1-carboxamide
CFAMM00044366 CHEMBL537000 Bioactive (3R)-3-amino-1-[8-prop-2-enyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
CFAMM00044316 CHEMBL1082202 Bioactive CHEMBL1081478
CFAMM00044412 CHEMBL522259 Bioactive 4,4-difluoro-N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]cyclohexane-1-carboxamide
CFAMM00044404 CHEMBL212437 Bioactive SureCN5635277
CFAMM00044352 CHEMBL472953 Bioactive N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]cyclopropanecarboxamide
CFAMM00044315 CHEMBL1649912 Bioactive 4,4-difluoro-N-[(1S)-3-[(1S,5R)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
CFAMM00044411 CHEMBL1203953 Bioactive (3R)-3-amino-1-[(8R)-8-[(4-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
CFAMM00044298 CHEMBL1087535 Bioactive N-[(1S)-3-[(1R,5S)-3-(3,5-dimethyl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-(3-fluorophenyl)propyl]-3,3-difluorocyclobutane-1-carboxamide
CFAMM00044322 CHEMBL473759 Bioactive N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]cyclohexanecarboxamide
CFAMM00044380 CHEMBL473558 Bioactive N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]cyclopentanecarboxamide
CFAMM00044344 CHEMBL539350 Bioactive (3R)-3-amino-1-[8-benzyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
CFAMM00044297 CHEMBL1087534 Bioactive N-[(1S)-3-[(1S,5R)-3-(3,5-dimethyl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-(3-fluorophenyl)propyl]oxolane-3-carboxamide
CFAMM00044303 CHEMBL217051 Bioactive Sitagliptin Analog 14
CFAMM00044379 CHEMBL515261 Bioactive 2-cyclopropyl-N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]acetamide
CFAMM00044394 CHEMBL491319 Bioactive 3,3-difluoro-N-[(1S,3R)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]cyclobutane-1-carboxamide
CFAMM00044408 CHEMBL491679 Bioactive 3,3-difluoro-N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]cyclobutane-1-carboxamide;hydrochloride
CFAMM00044401 CHEMBL536090 Bioactive (3R)-3-amino-1-[3-(trifluoromethyl)-8-[[2-(trifluoromethyl)phenyl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
CFAMM00044393 CHEMBL556606 Bioactive (3R)-3-amino-1-[8-ethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
CFAMM00044407 CHEMBL1087153 Bioactive N-[(1S)-3-[(1S,5R)-3-(3,5-dimethyl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-(3-fluorophenyl)propyl]-4,4-difluorocyclohexane-1-carboxamide
CFAMM00044369 CHEMBL474154 Bioactive 2-methyl-N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]propanamide
CFAMM00044348 CHEMBL455570 Bioactive 4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
CFAMM00044311 CHEMBL1081476 Bioactive N-[(1S)-3-[(3aR,6aS)-5-(3,5-dimethyl-1,2,4-triazol-4-yl)-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl]-1-(3-fluorophenyl)propyl]-3,3-difluorocyclobutane-1-carboxamide
CFAMM00044392 CHEMBL459571 Bioactive 4,4-difluoro-N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
CFAMM00044368 CHEMBL469724 Bioactive N-[(1S)-3-[4-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)piperidin-1-yl]-1-phenylbutyl]cyclobutanecarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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