CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD253
Family Name Cysteinyl leukotriene receptor 1 Ligand Montelukast Family
No. of Seeds 37 No. of Other Members 29
Family Centroid CFAMM00044471 Functional Category Approved Drug
Superfamily Cysteinyl leukotriene receptor 1 Ligand Montelukast Superfamily
Class Class 215

Cousin Family NamesSeedsMembers
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Canalicular multispecific organic anion transporter 1 Inhibito... 7 5
Squalene synthase inhibitor SureCN7761201 family 2 14
Cysteinyl leukotriene receptor 1 ligand (2S)-3-[(1S)-3-(2-acet... 6 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 30
Cysteinyl leukotriene receptor 1 and Cysteinyl leukotriene rec... 7 0
Cysteinyl leukotriene receptor 1 ligand 2-[1-[[(1R)-1-[3-[(E)-... 6 2
Cysteinyl leukotriene receptor 1 ligand 2-[1-[[(1R)-3-[2-(2-hy... 10 2
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 11 2
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00044471 DAP000309 Approved Drug Montelukast
CFAMM00044466 CHEMBL143597 Bioactive 2-[1-[[(1R)-3-[2-(2-hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5-methyl-6-propylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044481 CHEMBL345093 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(5-ethyl-6-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044422 CHEMBL358142 Bioactive 2-[1-[[(1R)-3-[2-(2-hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(6-propan-2-ylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044432 CHEMBL319802 Bioactive 4-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl-3-methylbutanoic acid
CFAMM00044459 CHEMBL15161 Bioactive L-695499
CFAMM00044487 CHEMBL344180 Bioactive 2-[1-[[(1R)-3-[2-(2-hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5,6,7,8-tetrahydroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044438 CHEMBL143788 Bioactive (2S)-3-[(1S)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[3-(hydroxymethyl)phenyl]propyl]sulfanyl-2-methylpropanoic acid
CFAMM00044451 CHEMBL141665 Bioactive (2S)-3-[(1S)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(hydroxymethyl)phenyl]propyl]sulfanyl-2-methylpropanoic acid
CFAMM00044465 CHEMBL341547 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(6-butyl-5-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044480 CHEMBL343934 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(7,7-dimethyl-6,8-dihydro-5H-quinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044421 CHEMBL84707 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(3-chlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044444 CHEMBL344756 Bioactive (2S)-3-[(1S)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-(2-ethoxycarbonylphenyl)propyl]sulfanyl-2-methylpropanoic acid
CFAMM00044458 CHEMBL314340 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(2-chlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044464 CHEMBL341814 Bioactive 2-[1-[[(1R)-3-[2-(2-hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(6-propylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044430 CHEMBL140761 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(5-chloro-6-ethylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044456 CHEMBL98676 Bioactive 3-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylbutanoic acid
CFAMM00044427 CHEMBL348229 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(8,8-dimethyl-6,7-dihydro-5H-quinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044449 CHEMBL95317 Bioactive (3R)-3-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylbutanoic acid
CFAMM00044478 CHEMBL143874 Bioactive (2S)-3-[(1S)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl-2-methylpropanoic acid
CFAMM00044429 CHEMBL327942 Bioactive (2S,3S)-3-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl-2-methylbutanoic acid
CFAMM00044419 CHEMBL95234 Bioactive (2R,3R)-3-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl-2-methylbutanoic acid
CFAMM00044455 CHEMBL141640 Bioactive 2-[1-[[(1R)-3-[2-(2-hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044426 CHEMBL330649 Bioactive (2S)-2-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]butanoic acid
CFAMM00044435 CHEMBL142803 Bioactive (2S)-3-[(1S)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxy-2-methylpropyl)phenyl]propyl]sulfanyl-2-methylpropanoic acid
CFAMM00044462 CHEMBL95362 Bioactive 3-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylpentanoic acid
CFAMM00044477 CHEMBL316688 Bioactive 3-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl-3-methylbutanoic acid
CFAMM00044428 CHEMBL99775 Bioactive Montelukast Gem-dimethylmethylene Analogue
CFAMM00044454 CHEMBL141234 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(6-ethyl-5-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044447 CHEMBL344169 Bioactive 2-[1-[[(1R)-3-[2-(2-hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5-methyl-6-propan-2-ylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044461 CHEMBL342784 Bioactive 2-[1-[[(1R)-3-[2-(2-hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-[5-methyl-6-(2-methylpropyl)pyridin-2-yl]ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044476 CHEMBL342705 Bioactive 2-[1-[[(1R)-3-[2-(2-hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(8-methyl-5,6,7,8-tetrahydroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044453 CHEMBL96986 Bioactive (3S)-3-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylbutanoic acid
CFAMM00044433 CHEMBL141841 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(5,6-dimethylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044424 CHEMBL341657 Bioactive 2-[1-[[(1R)-1-[3-[(E)-2-(6-butylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
CFAMM00044475 CHEMBL97576 Bioactive 3-[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl-2-methylbutanoic acid
CFAMM00044460 DNCL002033 Clinical Trial Drug Montelukast/mometasone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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