CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name D(2) dopamine receptor Ligand Remoxipride Family
No. of Seeds 12 No. of Other Members 84
Family Centroid CFAMM00044660 Functional Category Approved Drug with Natural Product
Superfamily D(2) dopamine receptor Ligand Remoxipride Superfamily
Class Class 35

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Sulpiride Family 7 38
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Insulin receptor Ligand Meglitinides Family 9 25
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
D(2) dopamine receptor and D(3) dopamine receptor ligand 5-bro... 3 11
D(2) dopamine receptor ligand (E)-2,3-dihydroxybut-2-enedioic ... 6 10
D(2) dopamine receptor ligand 2-bromo-3-chloro-N-[[(2S)-1-ethy... 1 1
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
D(2) dopamine receptor ligand 2-bromo-N-[[(2S)-1-ethylpyrrolid... 3 0
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
D(2) dopamine receptor ligand AGN-PC-0041GL family 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
Putative NP ZINC20762875 Family 7 1


External ID

Functional Category

Molecule Name

CFAMM00044660 DAP000312 Approved Drug Remoxipride
CFAMM00044600 CHEMBL161417 Bioactive 3-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-fluoro-2-hydroxy-6-methoxybenzamide
CFAMM00044644 CHEMBL175082 Bioactive 3-bromo-N-[[(2R)-1-[(4-fluorophenyl)methyl]pyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
CFAMM00044620 CHEMBL23437 Bioactive 3-bromo-2-hydroxy-6-methoxy-N-[[(2S)-1-propylpyrrolidin-2-yl]methyl]benzamide
CFAMM00044671 CHEMBL8475 Bioactive N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-3-iodo-6-methoxybenzamide
CFAMM00044628 CHEMBL2096749 Bioactive N-[[(2R)-1-benzylpyrrolidin-2-yl]methyl]-3-bromo-2-hydroxy-6-methoxybenzamide
CFAMM00044648 CHEMBL23464 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-iodo-2,6-dimethoxybenzamide
CFAMM00044597 CHEMBL1276645 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxy-3-methylbenzamide
CFAMM00044588 CHEMBL282925 Bioactive 3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxybenzamide
CFAMM00044596 CHEMBL1276350 Bioactive 3-butyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxybenzamide
CFAMM00044646 CHEMBL283099 Bioactive 3-bromo-n-{[(2s)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide
CFAMM00044663 DNC012389 Investigative Drug IBZM

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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