CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD259
Family Name D(2) dopamine receptor ligand diphenylbutylpiperidine derivative Pimozide Family
No. of Seeds 10 No. of Other Members 157
Family Centroid CFAMM00044905 Functional Category Approved Drug
Superfamily dopamine receptor ligand diphenylbutylpiperidine derivative Pimozide Fluspirilene Superfamily
Class Class 220

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Dopamine receptor Ligand Domperidone Family 2 21
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-P receptor Ligand Vestipitant Family 14 137
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Nociceptin receptor Ligand J-113397 Family 3 14
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Androgen receptor Ligand LG-121071 Family 8 32
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Reverse transcriptase Inhibitor Tibo Family 2 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Trypsin Inhibitor 1,3-di-p-tolyl-[1,3]diazetidine-2,4-dione Fa... 2 16
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
Cannabinoid receptor 2 ligand SureCN738026 family 5 68
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 1
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 7 18
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
Melanin-concentrating hormone receptor 1 ligand 3-(3-bromophen... 4 0
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,3,4-trifluorop... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 3
C-C chemokine receptor type 3 ligand 4-(5-amino-2-oxo-3H-benzi... 1 0
C-C chemokine receptor type 3 ligand (2S)-1-N-[(1R,5R)-8-[(6-f... 1 1
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 13
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
5-hydroxytryptamine receptor 4 ligand 6-fluoro-N-[[1-[(4-hydro... 1 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 1
Translocator protein inhibitor CHEMBL2332254 family 6 1
Histamine H3 receptor and Histamine receptor H3 ligand N-[4-[3... 5 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Tryptase alpha/beta-1 and Tryptase delta inhibitor SureCN75047... 4 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Neuropeptide Y receptor type 5 ligand 3-(4-benzylphenyl)-1-[(1... 2 4
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Sodium-dependent noradrenaline transporter inhibitor SureCN408... 5 12
Nociceptin receptor and Mu-type opioid receptor ligand spiropi... 1 0
Transient receptor potential cation channel subfamily V member... 1 1
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRYI family 2 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 3 5
Cannabinoid receptor 2 ligand SureCN738244 family 1 0
Melanin-concentrating hormone receptor 1 and Alpha-1A adrenerg... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 1 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Type-2 angiotensin II receptor ligand SureCN3515537 family 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Coagulation factor VII and Prothrombin inhibitor 2-[(4-carbami... 2 1
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
Mu-type opioid receptor ligand 1-[[(3S)-2-[[(2R)-1-[(4-cyanoph... 1 0
Mu-type opioid receptor ligand N-[4-[[(2R)-2-[[[(3S)-3-[(pheny... 1 0
Reverse transcriptase/RNaseH inhibitor (4S)-6-fluoro-4-(3-meth... 7 1
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Mu-type opioid receptor ligand 1-phenyl-3-[[(3S)-2-[[(2R)-1-(t... 1 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 7
Substance-P receptor ligand (2S)-2-N-[2-[(3,5-dimethylphenyl)m... 1 1
2,8-dimethyl-N-phenyl-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00044841 DAP001414 Approved Drug Oxatomide
CFAMM00044905 DAP000316 Approved Drug Pimozide
CFAMM00044868 CHEMBL490797 Bioactive 5-fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
CFAMM00044789 CHEMBL489576 Bioactive AGN-PC-077LPE
CFAMM00044781 CHEMBL511827 Bioactive SureCN3150574
CFAMM00044766 CHEMBL522460 Bioactive TBPB
CFAMM00044851 CHEMBL490598 Bioactive AGN-PC-077LOC
CFAMM00044911 CHEMBL521914 Bioactive AGN-PC-077LOD
CFAMM00044828 CHEMBL522451 Bioactive 6-fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one
CFAMM00044908 DCL000805 Clinical Trial Drug Flibanserin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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