CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Oestrogen receptor ligand steroid Estradiol derivative Fulvestrant Family
No. of Seeds 3 No. of Other Members 64
Family Centroid CFAMM00045044 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Oestrogen receptor ligand steroid Estradiol derivative Superfamily
Class Class 223

Cousin Family NamesSeedsMembers
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Oestrogen receptor ligand steroid Estradiol Family 18 147
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Mestranol Family 2 29
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
Steryl-sulfatase Inhibitor 2-ethylestradiol 3,17-o,o-bis-sulfa... 1 2
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Estrogen receptor and Estrogen receptor beta ligand SureCN1784... 1 2
Estrogen receptor and Estrogen receptor beta ligand 10-[(8S,9S... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3-bromophe... 1 1
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3,4-dichlo... 1 3
Aldo-keto reductase family 1 member C3 inhibitor (2R,8'R,9'S,1... 1 0
Aldo-keto reductase family 1 member C3 inhibitor methyl (8R,9S... 1 0


External ID

Functional Category

Molecule Name

CFAMM00045044 DAP000319 Approved Drug Fulvestrant
CFAMM00045023 CHEMBL1628165 Bioactive 4-[(8S,9S,11S,13S,14S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-11-yl]butyl methanesulfonate
CFAMM00044977 CHEMBL2036561 Bioactive (8S,9R,11S,13S,14S,17S)-13-methyl-11-[4-[5-(1,1,2,2,2-pentafluoroethylsulfonyl)pentoxy]phenyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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