CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD270
Family Name Histamine H1 receptor ligand tricyclic antidepressant Desloratadine Family
No. of Seeds 6 No. of Other Members 136
Family Centroid CFAMM00045747 Functional Category Approved Drug
Superfamily Histamine H1 receptor ligand tricyclic antidepressant Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Transient receptor potential cation channel subfamily V member... 16 295
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
ABC294640 family 5 75
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
D(4) dopamine receptor Ligand L-745,870 Family 30 205
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
5-hydroxytryptamine receptor 7 Ligand 2-[1-(2-chloro-phenyl)-1... 1 1
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonit... 7 2
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Prothrombin inhibitor SureCN7371121 family 13 3
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Histamine H1 receptor and Potassium voltage-gated channel subf... 5 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fl... 6 7
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 14 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
D(4) dopamine receptor and D(3) dopamine receptor ligand 1-(2,... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 1
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 0
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07R6NY family 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Corticotropin-releasing factor receptor 1 ligand 2-(2,4-dichlo... 2 2
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Beta-secretase 2 and Beta-secretase 1 inhibitor 2-cyclopropyl-... 1 1
Potassium voltage-gated channel subfamily A member 5 and Inter... 1 0
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (2Z)-... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2,3-dichlorop... 1 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Pyridines and Derivatives Metabolite (S)-Actinidine Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00045746 DAP000336 Approved Drug Chlorpheniramine
CFAMM00045747 DAP000331 Approved Drug Desloratadine
CFAMM00045745 DNC005871 Investigative Drug RUPATADINE
CFAMM00045784 DNC006308 Investigative Drug (2-(2-chlorophenyl)pyridin-3-yl)methanamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543