CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Histamine H1 receptor Ligand Azelastine Family
No. of Seeds 14 No. of Other Members 29
Family Centroid CFAMM00045831 Functional Category Approved Drug
Superfamily Histamine H1 receptor Ligand Azelastine Superfamily
Class Class 230

Cousin Family NamesSeedsMembers
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Poly [ADP-ribose] polymerase 1 Inhibitor KU-0059436 Family 21 45
Neuromedin-K receptor Ligand Osanetant Family 38 192
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Poly [ADP-ribose] polymerase 1 Inhibitor 4-benzylphthalazin-1(... 2 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 7 9
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Histamine H3 receptor ligand 2-methyl-6-[4-[(2S)-2-(pyrrolidin... 1 1
Histamine H3 receptor ligand 2-methyl-6-[4-[2-[(2R)-2-methylpy... 2 4
Progesterone receptor ligand 2-[(3,4-dichlorophenyl)methyl]-6-... 1 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 0


External ID

Functional Category

Molecule Name

CFAMM00045831 DAP000332 Approved Drug Azelastine
CFAMM00045839 CHEMBL1767134 Bioactive HL 2197
CFAMM00045838 CHEMBL1767135 Bioactive 4-[(4-chlorophenyl)methyl]-2-[3-(dimethylamino)propyl]phthalazin-1-one
CFAMM00045829 CHEMBL1767154 Bioactive 4-[(4-chlorophenyl)methyl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methyl]phthalazin-1-one
CFAMM00045837 CHEMBL1767158 Bioactive 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-3-yl)phthalazin-1-one
CFAMM00045828 CHEMBL1767155 Bioactive 4-[(4-chlorophenyl)methyl]-2-[(1-methylpyrrolidin-3-yl)methyl]phthalazin-1-one
CFAMM00045827 CHEMBL1767156 Bioactive 4-[(4-chlorophenyl)methyl]-2-(1-methylpiperidin-4-yl)phthalazin-1-one
CFAMM00045804 CHEMBL1767146 Bioactive 4-[(3-chlorophenyl)methyl]-2-[[(2R)-1-methylpyrrolidin-2-yl]methyl]phthalazin-1-one
CFAMM00045791 CHEMBL2146802 Bioactive 2-[[(2R)-1-butylpyrrolidin-2-yl]methyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one
CFAMM00045841 CHEMBL1767136 Bioactive 4-[(4-chlorophenyl)methyl]-2-[[(2R)-1-methylpyrrolidin-2-yl]methyl]phthalazin-1-one
CFAMM00045790 CHEMBL2146803 Bioactive 4-[(4-chlorophenyl)methyl]-2-[[(2R)-1-(2-methoxyethyl)pyrrolidin-2-yl]methyl]phthalazin-1-one
CFAMM00045809 DNC013017 Investigative Drug 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one
CFAMM00045820 DNC000270 Investigative Drug Azelastine hydrochloride
CFAMM00045813 DNC013018 Investigative Drug 4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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