CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Muscarinic acetylcholine receptor M5 ligand phenothiazine derivative Promazine Family
No. of Seeds 8 No. of Other Members 37
Family Centroid CFAMM00045853 Functional Category Approved Drug
Superfamily Biogenic amine receptor, Calmodulin binding phenothiazine Superfamily
Class Class 32

Cousin Family NamesSeedsMembers
Calmodulin inhibitor phenothiazine derivative Trifluoperazine ... 3 30
D(2) dopamine receptor Ligand phenothiazine analog Prochlorper... 4 25
Alpha adrenergic receptor ligand phenothiazine derivative Thio... 4 10
Alpha-1B adrenergic receptor Ligand Propericiazine Family 2 0
Sodium channel protein type 5 subunit alpha Ligand Moricizine ... 1 0
Histamine H1 receptor ligand phenothiazine derivative Mequitaz... 3 2
Mannose-6-phosphate isomerase Inhibitor Sulfoxone Family 3 20
5-hydroxytryptamine receptor Ligand Lu AA21004 Family 13 39
5-hydroxytryptamine receptor 6 Ligand 4-(4-benzenesulfonamidop... 4 5
Cholinesterase Inhibitor 1,2-di(10h-phenothiazin-10-yl)ethane-... 1 0
Cholinesterase Inhibitor Butyl 10h-phenothiazine-10-carboxylat... 4 3
D(2) dopamine receptor Ligand 1-benzyl-4-[3-(methylsulfonyl)ph... 2 7
Cholinesterase Inhibitor N-cyclohexyl-1'h-phenothiazine-1'-car... 7 2
Cholinesterase Inhibitor N-p-tolyl-1'h-phenothiazine-1'-carbox... 4 1
Cholinesterase Inhibitor Morpholino(1'h-phenothiazin-1'-yl)met... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 18 12
Sodium-dependent serotonin transporter and Transporter inhibit... 4 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sigma non-opioid intracellular receptor 1 ligand 3-[4-(azepan-... 8 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-00JBJI family 1 1


External ID

Functional Category

Molecule Name

CFAMM00045848 DAP000334 Approved Drug Promethazine
CFAMM00045853 DAP000430 Approved Drug Promazine
CFAMM00045882 DAP001070 Approved Drug Methdilazine
CFAMM00045874 DAP001077 Approved Drug Trimeprazine
CFAMM00045861 DAP001119 Approved Drug Ethopropazine
CFAMM00045900 DNC010565 Investigative Drug N,N-Diethyl-1'H-phenothiazine-1'-carboxamide
CFAMM00045892 DNC010566 Investigative Drug N,N-Dipropyl-1'H-phenothiazine-1'-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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