CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD275
Family Name Histamine H1 receptor ligand piperazine derivative Cyclizine Family
No. of Seeds 16 No. of Other Members 140
Family Centroid CFAMM00046031 Functional Category Approved Drug with Natural Product
Superfamily calcium channel, Histamine H1 receptor, nuclear receptor binding piperazine derivative Flunarizine Cyclizine Meclizine Superfamily
Class Class 115

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Bethanidine Family 2 22
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Beta adrenergic receptor Ligand Bretylium Family 3 11
Calmodulin Inhibitor Aprindine Family 1 4
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Dermatan family 1 11
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
Substance-P receptor Ligand Orvepitant Family 11 46
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Substance-P receptor Ligand Vestipitant Family 14 137
Bavisant family 9 65
Pitolisant family 4 24
Zicronapine family 43 62
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Peptide deformylase, mitochondrial Inhibitor [hydroxy(3-phenyl... 1 0
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 2 39
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 12 20
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
Sphingosine 1-phosphate receptor 1 Ligand [3-(4-nonyl-benzylam... 9 22
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Sodium-dependent serotonin transporter Inhibitor 2-n-ethylamin... 14 5
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 7 1
Vesicular acetylcholine transporter inhibitor (3R,4R)-1-[(3-io... 17 20
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
D(1A) dopamine receptor and 5-hydroxytryptamine receptor 2A li... 2 0
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 34
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-methoxy-1-[(2S)-... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor Sodium... 1 10
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 8 6
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-[2-[4-[1-ad... 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Histamine H3 receptor ligand 4-[4-[4-(piperidin-1-ylmethyl)phe... 3 5
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
Histamine H3 receptor ligand SureCN1641166 family 3 0
Histamine H3 receptor ligand 4-[6-(2-pyrrolidin-3-ylethyl)naph... 1 1
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Histamine H3 receptor ligand (3aR,6aR)-2-propan-2-yl-4-[4-(2-p... 6 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 0
Sodium-dependent serotonin transporter and Transporter inhibit... 2 8
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
D(2) dopamine receptor ligand AGN-PC-041NNJ family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Sigma non-opioid intracellular receptor 1 ligand [(2R)-1,4-dib... 1 4
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Prelamin-A/C and Nuclear receptor ROR-gamma ligand Sulbentine ... 1 1
C-X-C chemokine receptor type 3 ligand [4-(2-bromophenyl)pheny... 1 2
Melanocortin receptor 4 ligand 1-[3-[2-(4-tert-butylphenyl)phe... 1 3
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Glutamate receptor ionotropic, NMDA 2C ligand (NE)-N-[[3-[1-(3... 1 0
Acetylcholinesterase inhibitor (E)-1-N'-benzyl-1-N-[2-(1-benzy... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor (1... 3 0
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00046031 DAP000337 Approved Drug Cyclizine
CFAMM00046062 DAP001147 Approved Drug Benzphetamine
CFAMM00046066 CHEMBL1907650 Bioactive N-methyl-5-phenyl-N-[(2S)-1-phenylpropan-2-yl]pentan-1-amine
CFAMM00046058 CHEMBL457006 Bioactive N,N-dimethyl-1-[4-[4-(piperidin-1-ylmethyl)phenyl]phenyl]methanamine
CFAMM00045937 CHEMBL1917697 Bioactive (E)-N-benzyl-N-methyl-3-(4-phenylphenyl)but-2-en-1-amine;hydrochloride
CFAMM00045943 CHEMBL39855 Bioactive 1-benzyl-3-[(E)-2-phenylethenyl]piperidine
CFAMM00045992 CHEMBL209478 Bioactive 1-[4-[4-[(dimethylamino)methyl]phenyl]phenyl]-N,N-dimethylmethanamine
CFAMM00046049 CHEMBL500825 Bioactive N-[[4-[4-(diethylaminomethyl)phenyl]phenyl]methyl]-N-ethylethanamine
CFAMM00046015 CHEMBL19314 Bioactive AGN-PC-022JBO
CFAMM00046028 CHEMBL146238 Bioactive SureCN6512477
CFAMM00046060 CHEMBL224099 Bioactive (E)-N-benzyl-N-methyl-3-(4-phenylphenyl)but-2-en-1-amine
CFAMM00046040 CHEMBL458718 Bioactive N-[[4-[4-[(dipropylamino)methyl]phenyl]phenyl]methyl]-N-propylpropan-1-amine
CFAMM00046039 DCL000689 Clinical Trial Drug Alphagen
CFAMM00045982 DNC011875 Investigative Drug PHENCYCLIDINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543