CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Endothelin B receptor and Endothelin-1 receptor ligand pyrimidine sulfonamide derivative Bosentan family
No. of Seeds 22 No. of Other Members 180
Family Centroid CFAMM00007283 Functional Category Approved Drug
Superfamily Endothelin B receptor and Endothelin-1 receptor ligand pyrimidine sulfonamide derivative Bosentan Superfamily
Class Class 28

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Tezosentan family 4 5
Macitentan family 18 1
Deoxycytidine kinase inhibitor AGN-PC-07Z9C8 family 5 3
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 17 3
Endothelin-1 receptor ligand AGN-PC-075B4O family 7 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 4 2
Endothelin-1 receptor ligand SureCN8801173 family 3 0
Endothelin-1 receptor ligand AGN-PC-00GZJQ family 12 0
Endothelin-1 receptor ligand SureCN8657460 family 1 0
Endothelin-1 receptor ligand AGN-PC-075B4U family 3 0
Endothelin B receptor and Endothelin-1 receptor ligand SureCN7... 1 2
Endothelin B receptor and Endothelin-1 receptor ligand N-[5-(2... 2 1
Endothelin-1 receptor ligand AGN-PC-00FQOK family 4 0
Endothelin-1 receptor and Endothelin B receptor ligand 6-[2-(5... 3 1
Endothelin-1 receptor and Endothelin B receptor ligand 6-[2-(5... 7 0
Endothelin-1 receptor and Endothelin B receptor ligand N-(benz... 4 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Endothelin-1 receptor and Endothelin B receptor ligand SureCN8... 1 0
Endothelin B receptor ligand RO468443 family 1 0


External ID

Functional Category

Molecule Name

CFAMM00007283 DAP000030 Approved Drug Bosentan
CFAMM00007224 CHEMBL2163697 Bioactive 4-tert-butyl-N-[5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-6-(2-pyrimidin-2-yloxyethoxy)pyrimidin-4-yl]benzenesulfonamide
CFAMM00007150 CHEMBL71070 Bioactive AGN-PC-074GWK
CFAMM00007177 CHEMBL70487 Bioactive SureCN8328410
CFAMM00007122 CHEMBL114105 Bioactive 4-tert-butyl-N-[5-(3-methoxyphenoxy)-6-(2-pyridin-2-yloxyethoxy)pyrimidin-4-yl]benzenesulfonamide
CFAMM00007278 CHEMBL303428 Bioactive AGN-PC-074GWL
CFAMM00007196 CHEMBL166875 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(2-methoxyphenoxy)-2-methylpyrimidin-4-yl]-4-tert-butylbenzenesulfonamide
CFAMM00007114 CHEMBL70800 Bioactive AGN-PC-074GTQ
CFAMM00007135 CHEMBL2163708 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]-4-tert-butylbenzenesulfonamide
CFAMM00007128 CHEMBL2163702 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]-2-phenylethanesulfonamide
CFAMM00007214 CHEMBL170908 Bioactive AGN-PC-0757BM
CFAMM00007113 CHEMBL113757 Bioactive 4-tert-butyl-N-[6-[2-(5-methoxypyrimidin-2-yl)oxyethoxy]-5-(4-methylphenyl)pyrimidin-4-yl]benzenesulfonamide
CFAMM00007127 CHEMBL2163703 Bioactive N-[5-(2-methoxyphenoxy)-6-[2-(5-methoxypyrimidin-2-yl)oxyethoxy]-2-pyrimidin-2-ylpyrimidin-4-yl]-2-phenylethanesulfonamide
CFAMM00007255 CHEMBL70203 Bioactive SureCN8320276
CFAMM00007133 CHEMBL2163704 Bioactive N-[5-(2-methoxyphenoxy)-6-[2-(5-methylsulfanylpyrimidin-2-yl)oxyethoxy]-2-pyrimidin-2-ylpyrimidin-4-yl]-2-phenylethanesulfonamide
CFAMM00007159 CHEMBL2163711 Bioactive N-[6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]-3-phenylpropane-1-sulfonamide
CFAMM00007226 CHEMBL2163698 Bioactive N-[5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-6-(2-pyrimidin-2-yloxyethoxy)pyrimidin-4-yl]-2-phenylethanesulfonamide
CFAMM00007132 CHEMBL2163705 Bioactive N-[5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-6-[2-[5-(trifluoromethyl)pyrimidin-2-yl]oxyethoxy]pyrimidin-4-yl]-2-phenylethanesulfonamide
CFAMM00007219 CHEMBL70339 Bioactive 2-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-morpholin-4-ylpyrimidin-4-yl]oxyethyl N-pyridin-2-ylcarbamate
CFAMM00007194 DCL000710 Clinical Trial Drug Avosentan
CFAMM00007249 DNC003692 Investigative Drug BOSENTAN SODIUM
CFAMM00007192 DNC000341 Investigative Drug Bosentan hydrate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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