CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD283
Family Name Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family
No. of Seeds 3 No. of Other Members 73
Family Centroid CFAMM00046243 Functional Category Approved Drug with Natural Product
Superfamily Muscarinic acetylcholine receptor M4 Ligand Tropicamide Superfamily
Class Class 240

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Prothrombin Inhibitor Ximelegatran Family 8 157
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Substance-P receptor Ligand TAK-637 Family 18 63
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
FK506-binding protein 1A Inhibitor Gpi-1046 Family 4 10
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor Cycl... 1 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 2 24
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 2 1
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 4 8
C-C chemokine receptor type 5 ligand AC1LA259 family 1 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
Sterol O-acyltransferase 1 inhibitor dodecyl 3-[2,6-di(propan-... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Cytochrome P450 2C19 inhibitor AGN-PC-07CPMJ family 1 0
Receptor-type tyrosine-protein phosphatase beta ligand AGN-PC-... 1 2
Potassium voltage-gated channel subfamily A member 5 ligand AG... 4 0
Fatty-acid amide hydrolase 1 inhibitor [(1R)-1-[(3S)-2-oxo-1-p... 1 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-[[2-[3... 4 0
Amino Acids and Derivatives Metabolite Allodesmosine Family 2 0
heptanamide NP ZINC08740384 Family 7 0
NP (2-methyl-5-(prop-1-en-2-yl)cyclopent-1-en-1-yl)methyl Ison... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00046243 DAP000345 Approved Drug Tropicamide
CFAMM00046234 DNC014464 Investigative Drug (+/-)-threo-N-(3-Methylpyridine)methylphenidate
CFAMM00046233 DNC014465 Investigative Drug (+/-)-threo-N-(4-Methylpyridine)methylphenidate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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