CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD286
Family Name Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocurine Family
No. of Seeds 18 No. of Other Members 169
Family Centroid CFAMM00046363 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Nicotinic acetylcholine receptor ligand bisbenzyltetrahydroisoquinolinium Superfamily
Class Class 92

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Nicotinic acetylcholine receptor alpha subunit Ligand benzylis... 4 18
Nicotinic acetylcholine receptor Ligand Cisatracurium Besylate... 1 0
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Glaziovine family 1 4
Endothelin-1 receptor Ligand Atrasentan Family 127 336
D(3) dopamine receptor Ligand U-99194A Family 7 33
Acolbifene family 10 115
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-br... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Cytochrome P450 3A4 Inhibitor 1,2-diacetoxylycorine Family 4 19
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
D(2) dopamine receptor Ligand (s)-secoantioquine Family 1 10
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
5-hydroxytryptamine receptor 1A ligand SureCN7035190 family 10 17
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
D(1A) dopamine receptor ligand DOXANTHINE family 3 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Transient receptor potential cation channel subfamily V member... 14 7
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melanin-concentrating hormone receptor 1 ligand 6-methoxy-4-[[... 2 15
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Endothelin-1 receptor ligand 2-[(1R,3S)-1-(1,3-benzodioxol-5-y... 3 10
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Benzazepines Metabolite N-Methylporphyroxine Family 1 2
Putative NP ZINC12858318 Family 42 0
Putative NP ZINC12660125 Family 8 0
7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline NP ZINC33345333... 21 3
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC04287792 Family 2 0
Putative NP ZINC01322649 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00046364 DAP000351 Approved Drug Tubocurarine
CFAMM00046385 DAP000824 Approved Drug Metocurine Iodide
CFAMM00046363 DAP000352 Approved Drug Metocurine
CFAMM00046490 DNC013982 Investigative Drug ISOTETRANDRINE
CFAMM00046489 DNC013983 Investigative Drug O-methyldauricine
CFAMM00046507 DNC013750 Investigative Drug (S,R)-antioquine hydrochloride
CFAMM00046488 DNC013980 Investigative Drug ANTIOQUINE
CFAMM00046416 DNC013743 Investigative Drug (+)-(1R,1'S)-thaligrisine hydrochloride
CFAMM00046415 DNC013744 Investigative Drug (+)-(1R,1'S)-berbamunine hydrochloride
CFAMM00046487 DNC013981 Investigative Drug OBABERINE
CFAMM00046486 DNC013984 Investigative Drug HOMOAROMOLINE
CFAMM00046588 DNC013667 Investigative Drug 1,2-Bis-[R-(-)-apomorphine-2'-oxy]ethane
CFAMM00046414 DNC013745 Investigative Drug (-)-(1S,1'R)-O,O-dimethylgrisbine hydrochloride
CFAMM00046502 DNC013916 Investigative Drug CEPHARANTINE
CFAMM00046624 DNC013979 Investigative Drug DIMETHYLGRISABINE
CFAMM00046587 DNC013666 Investigative Drug Bis-{[R-(-)-apomorphine-2-oxy]ethyl} ether
CFAMM00046413 DNC013746 Investigative Drug (R,S)-homoaromaline hydrochloride
CFAMM00046412 DNC013748 Investigative Drug (S,R)-isotetrandrine hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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