CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Substance-P receptor Ligand Aprepitant Family
No. of Seeds 4 No. of Other Members 8
Family Centroid CFAMM00046847 Functional Category Approved Drug with Human Metabolite
Superfamily Substance-P receptor Ligand Aprepitant Superfamily
Class Class 244

Cousin Family NamesSeedsMembers
Substance-P receptor Ligand L-733060 Family 19 71
Substance-P receptor ligand (1S)-2-[[3,5-bis(trifluoromethyl)p... 1 2
Substance-P receptor and Potassium voltage-gated channel subfa... 6 0
Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1


External ID

Functional Category

Molecule Name

CFAMM00046847 DAP000362 Approved Drug Aprepitant
CFAMM00046845 CHEMBL142819 Bioactive Defluoro Aprepitant
CFAMM00046849 DNC000952 Investigative Drug MK-869
CFAMM00046837 DNC004436 Investigative Drug L-741671

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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