CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD294
Family Name 5-hydroxytryptamine receptor 3A Ligand Dolasetron Family
No. of Seeds 12 No. of Other Members 171
Family Centroid CFAMM00047670 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily 5-hydroxytryptamine receptor 3A Ligand Dolasetron Superfamily
Class Class 247

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
AP endonuclease APE1 Inhibitor 5-fluoro-1h-indole-2-carboxylic... 2 61
Tyrosine-protein phosphatase non-receptor type 1 Ligand 6-(oxa... 1 5
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Tyrosine-protein phosphatase non-receptor type 1 Ligand Cauler... 2 8
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Arachidonate 5-lipoxygenase Inhibitor Methyl 2-(benzylamino)-1... 3 10
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Isoqui... 1 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 6-phenylethynyl-nicot... 2 26
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
5-hydroxytryptamine receptor 3A Ligand 3alpha-(1'-methyl-2'-in... 2 17
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Cholecystokinin receptor type A ligand A-65186 family 2 6
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 3 4
NS5B protein inhibitor AC1NQMYG family 6 12
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 1
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Survival motor neuron protein and Menin inhibitor CHEMBL130937... 1 7
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
Androgen receptor ligand ethyl 1-benzyl-2,5-dimethyl-4-(4-nitr... 2 7
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
RAC-beta serine/threonine-protein kinase inhibitor SureCN57283... 2 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Muscarinic acetylcholine receptor M1 and Cytochrome P450 2C19 ... 1 4
Huntingtin and Alkaline phosphatase, tissue-nonspecific isozym... 1 5
TGF-beta receptor type-1 ligand Methyl 4-(4-(3-(pyridin-2-yl)-... 1 2
Bifunctional epoxide hydrolase 2 inhibitor ethyl 1-[[4-[(1-ada... 7 5
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Neutrophil elastase inhibitor SureCN8210283 family 2 2
Glycine receptor subunit alpha-1 ligand [(1R,5R)-8-azabicyclo[... 2 10
Caspase-1 inhibitor (3S)-5-[2-(1H-indol-3-yl)acetyl]oxy-4-oxo-... 1 0
Serine/threonine-protein kinase pim-3 inhibitor methyl 6-amino... 1 2
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
Protease inhibitor AC1NUJZ5 family 1 0
Phenylpiperazines Metabolite Antrafenine Family 1 1
Putative NP ZINC15919780 Family 2 0
methyl 4-[(5Z)-5-(1H-indol-3-ylmethylidene)-4-oxo-2-sulfanylid... 1 0
2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium-8-carboxylate N... 2 0
2-(4-ethoxycarbonyl-5-methyl-1H-pyrrol-3-yl)-4-(4-methylphenyl... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00047622 DAP001534 Approved Drug Tropisetron
CFAMM00047670 DAP000368 Approved Drug Dolasetron
CFAMM00047583 CHEMBL108799 Bioactive SureCN14678609
CFAMM00047648 CHEMBL556193 Bioactive AGN-PC-07C2OE
CFAMM00047595 CHEMBL111583 Bioactive AGN-PC-00IQWT
CFAMM00047647 CHEMBL1632154 Bioactive AGN-PC-09QHKH
CFAMM00047601 CHEMBL1456417 Bioactive 3-Tropanylindole-3-carboxylate methiodide
CFAMM00047550 CHEMBL2130744 Bioactive TROPISETRON HCl
CFAMM00047484 DNC001279 Investigative Drug SB 203186
CFAMM00047559 DNC004414 Investigative Drug MDL-74156
CFAMM00047588 DNC001403 Investigative Drug TA1-RTA
CFAMM00047599 DNC006471 Investigative Drug ethyl 3-(pyridin-4-yl)-1H-indole-6-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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