CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD295
Family Name Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family
No. of Seeds 8 No. of Other Members 171
Family Centroid CFAMM00047815 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Muscarinic acetylcholine receptor M3 Ligand Tolterodine Superfamily
Class Class 248

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha-2 adrenergic receptor Ligand Oxymetazoline Family 5 4
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Oestrogen receptor ligand Dienestrol Family 35 440
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Thymopentin family 20 133
Oestrogen receptor ligand Fosfestrol Family 1 20
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
D(2) dopamine receptor Ligand N-0923 Family 6 41
D(3) dopamine receptor Ligand U-99194A Family 7 33
CORT-108297 family 46 44
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Bile acid receptor Ligand SR-45023A (apomine) Family 3 34
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Mu-type opioid receptor Ligand Cyprodime Family 12 8
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
D(1A) dopamine receptor Ligand 5-(2-amino-ethyl)-2-chloro-phen... 1 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Tubulin beta chain Inhibitor Colchinol Family 3 109
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
D(3) dopamine receptor ligand S 14297 family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
D(1A) dopamine receptor ligand (5S)-5-(4-azidophenyl)-8-iodo-3... 2 0
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
D(2) dopamine receptor and D(1A) dopamine receptor ligand (6aR... 2 4
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand 4-... 1 3
Histamine H3 receptor ligand SureCN6071181 family 2 1
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand Biom... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5
DNA polymerase beta and Thioredoxin glutathione reductase inhi... 1 5
Alpha-2A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Phenethylamines Metabolite Tyramine-O-sulfate Family 1 1
Phenylpropenes Metabolite N1,N5,N10,N14-Tetra-trans-p-coumaroy... 1 0
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00047815 DAP000376 Approved Drug Tolterodine
CFAMM00047864 DNC010076 Investigative Drug (-)-5-hydroxy-2-(dipropylamino)tetralin
CFAMM00047704 DNC012632 Investigative Drug 6-(2-Dipropylamino-ethyl)-biphenyl-2,3,4'-triol
CFAMM00047819 DNC011564 Investigative Drug 4-{2-[Ethyl-(4-phenyl-butyl)-amino]-ethyl}-phenol
CFAMM00047796 DNC012614 Investigative Drug 6-(2-Dipropylamino-ethyl)-biphenyl-2,3-diol
CFAMM00047756 DNC011593 Investigative Drug 4-[3-(5-Phenyl-pentylamino)-propyl]-phenol
CFAMM00047851 DNC013668 Investigative Drug (+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin
CFAMM00047806 DNC003429 Investigative Drug 4-(2-aminoethyl)-2-cyclohexylphenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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