CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Muscarinic acetylcholine receptor M5 ligand Tropane alkaloid Atropine Family
No. of Seeds 18 No. of Other Members 12
Family Centroid CFAMM00047912 Functional Category Approved Drug
Superfamily Muscarinic acetylcholine receptor ligand Tropane alkaloid Atropine Scopolamine Superfamily
Class Class 238

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Histamine H1 receptor Ligand Levocabastine Family 1 1
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Muscarinic acetylcholine receptor M2 ligand Tropane alkaloid S... 7 16
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
Muscarinic acetylcholine receptor Ligand Mepenzolate Family 35 11
Muscarinic acetylcholine receptor M1 Ligand Oxyphenonium Family 12 5
Mu-type opioid receptor Ligand Diphenoxylate Family 5 6
Sodium-dependent dopamine transporter Inhibitor Ioflupane I-12... 130 181
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 8 30
C-C chemokine receptor type 5 ligand AC1L9U8N family 8 6
C-C chemokine receptor type 5 ligand (2R)-3-cyclopropyl-2-[(3S... 10 4
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 18
Muscarinic acetylcholine receptor M3 ligand (1,1-dimethylpiper... 7 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 0
Transporter and Sodium-dependent serotonin transporter inhibit... 8 6
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
Sodium-dependent serotonin transporter and Transporter inhibit... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor me... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4


External ID

Functional Category

Molecule Name

CFAMM00047893 DAP001112 Approved Drug Ipratropium
CFAMM00047917 DNAP001613 Approved Drug Anisodamine
CFAMM00047912 DAP000377 Approved Drug Atropine
CFAMM00047898 CHEMBL376897 Bioactive Methylscopolamine
CFAMM00047886 CHEMBL1201024 Bioactive Hyoscine Methobromide
CFAMM00047892 CHEMBL516476 Bioactive DSSTox_CID_25543
CFAMM00047906 CHEMBL1628649 Bioactive [3H]NMS
CFAMM00047903 CHEMBL9751 Bioactive hyoscyamine
CFAMM00047915 CHEMBL1256901 Bioactive Butylhyoscine
CFAMM00047902 CHEMBL1908368 Bioactive ipratropium bromide
CFAMM00047922 DNCL002808 Clinical Trial Drug Levosalbutamol/ipratropium
CFAMM00047887 DNC000155 Investigative Drug Actoferrin
CFAMM00047909 DNC000758 Investigative Drug Hyoscyamine sulfate
CFAMM00047890 DNC000806 Investigative Drug Ipratropium bromide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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