CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD314
Family Name Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family
No. of Seeds 9 No. of Other Members 243
Family Centroid CFAMM00049500 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Superfamily
Class Class 255

Cousin Family NamesSeedsMembers
Enoyl-[acyl-carrier-protein] reductase [NADH] inhibitor pyridi... 3 24
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
DNA topoisomerase 2-beta Inhibitor Rosoxacin Family 1 5
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
26S proteasome Inhibitor Bortezomib Family 7 65
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Neuromedin-K receptor Ligand SB222200 Family 17 235
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
ABC294640 family 5 75
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
CP-18770 family 6 27
Pixantrone family 2 3
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Cyclin-dependent kinase 8 Inhibitor Oxindole 94 Family 2 3
FK506-binding protein 1A Inhibitor Gpi-1046 Family 4 10
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Aromatase Inhibitor Rogletimide Family 1 2
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
Platelet-derived growth factor receptor alpha and Platelet-der... 2 1
Dual specificity mitogen-activated protein kinase kinase 1 Inh... 2 7
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... 2 9
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family 3 14
M-phase inducer phosphatase 2 Inhibitor 6,7-dibromoquinoline-5... 1 2
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 2-phenylethynyl-7,8-d... 1 2
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
Amine oxidase [flavin-containing] A Inhibitor 6-chloro-n-(2-mo... 5 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 4
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... 2 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 2 24
Cholecystokinin receptor type A ligand A-65186 family 2 6
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-(3-pyri... 1 6
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 2 1
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Histamine H3 receptor ligand SureCN1857507 family 1 4
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Motilin receptor ligand SureCN2768052 family 3 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Progesterone receptor ligand (8S,11R,13S,14S,16R,17S)-17-(cycl... 11 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (7S)-... 2 19
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Thromboxane-A synthase inhibitor (Z)-2-bromo-3-[4-(pyridin-3-y... 1 0
Peptide deformylase inhibitor N-[(2R)-2-(cyclopentylmethyl)-3-... 1 1
Amine oxidase [flavin-containing] A inhibitor CHEMBL1917530 fa... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor 6-(3... 1 3
Histone deacetylase 6 and Histone deacetylase 8 inhibitor N-hy... 1 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Prelamin-A/C and Excitatory amino acid transporter 1 inhibitor... 1 0
Aromatase and Steroid 17-alpha-hydroxylase/17,20 lyase inhibit... 1 0
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Vesicular acetylcholine transporter and Sigma non-opioid intra... 2 0
DNA topoisomerase 4 subunit A inhibitor SureCN2388284 family 2 0
Fatty-acid amide hydrolase 1 inhibitor [(1R)-1-[(3S)-2-oxo-1-p... 1 2
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 1
C-X-C chemokine receptor type 2 ligand 6-chloro-N-(4-fluorophe... 1 0
Pyridines and Derivatives Metabolite 4-Hydroxy-4-(3-pyridyl)-b... 1 2
Pyridines and Derivatives Metabolite (R)-Boschniakine Family 1 0
Pyridines and Derivatives Metabolite (S)-Actinidine Family 1 0
Pyridines and Derivatives Metabolite Rotundine A Family 1 0
Naphthyridines Metabolite 3-Acetyl-2,7-naphthyridine Family 1 4
3-[(3S)-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]-N-pyr... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00049500 DAP000424 Approved Drug Metyrapone
CFAMM00049388 DNC011474 Investigative Drug 1-Phenyl-2-pyridin-3-yl-propan-1-one
CFAMM00049405 DNC000488 Investigative Drug CV-6504
CFAMM00049334 DNC009833 Investigative Drug N-hydroxy-8-oxo-8-(pyridin-3-yl)octanamide
CFAMM00049431 DNC003137 Investigative Drug (4-fluorophenyl)(pyridin-4-yl)methanone
CFAMM00049430 DNC000489 Investigative Drug CV-6504 HCl
CFAMM00049507 DNC009470 Investigative Drug LOPHOCLADINE A
CFAMM00049337 DNC011434 Investigative Drug 2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-one
CFAMM00049364 DNC007857 Investigative Drug 1,10-phenanthroline-5,6-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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