CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Delta-type opioid receptor Ligand Loperamide Family
No. of Seeds 8 No. of Other Members 55
Family Centroid CFAMM00049618 Functional Category Approved Drug with Human Metabolite
Superfamily dopamine receptor ligand Haloperido,l opioid receptor ligand Loperamide Superfamily
Class Class 218

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Terfenadine Family 3 50
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Melanocortin receptor 4 and Melanocortin receptor 3 ligand Sur... 6 53
C-C chemokine receptor type 5 ligand N-[1-[[(3S,4R)-1-(cyclope... 1 16
C-C chemokine receptor type 1 ligand SureCN7463390 family 1 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-04TFA0... 1 0
Substance-K receptor ligand AGN-PC-0759BS family 3 6
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Renin inhibitor SureCN1865980 family 9 4
Renin and Potassium voltage-gated channel subfamily H member 2... 3 0
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
C-C chemokine receptor type 5 ligand (2R)-3-cyclopropyl-2-[(3S... 6 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 1 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[(4S)-4-(4-chlo... 15 6
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
C-C chemokine receptor type 1 ligand N-[(2R)-1-[(4S)-4-(4-chlo... 1 0
Substance-P receptor and Substance-K receptor ligand N-[(2Z)-3... 5 0
Melanin-concentrating hormone receptor 1 and Alpha-1A adrenerg... 1 0


External ID

Functional Category

Molecule Name

CFAMM00049618 DAP000425 Approved Drug Loperamide
CFAMM00049586 CHEMBL186300 Bioactive AGN-PC-075G7G
CFAMM00049600 CHEMBL186795 Bioactive 4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
CFAMM00049579 CHEMBL186938 Bioactive AGN-PC-075G6X
CFAMM00049583 CHEMBL2303637 Bioactive AGN-PC-04RHEQ
CFAMM00049576 CHEMBL1707 Bioactive Loperamide hydrochloride
CFAMM00049581 CHEMBL1627 Bioactive N-desmethyl loperamide
CFAMM00049578 DNC005112 Investigative Drug FLUPERAMIDE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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