CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFAD317
Family Name Melatonin receptor type 1A Ligand Melatonin Family
No. of Seeds 20 No. of Other Members 988
Family Centroid CFAMM00050829 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Melatonin receptor type 1A Ligand Melatonin Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
DNA Binder Primaquine Family 3 245
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Apricoxib family 8 77
Indeglitazar family 3 39
PF-02545920 family 16 140
8-aminoquinoline Inhibitor Tafenoquine Family 1 0
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Integrin beta-3 Inhibitor L-756568 Family 8 59
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Glycogen synthase kinase-3 beta Inhibitor 6-hydroxymanzamine A... 3 0
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
Progesterone receptor Ligand PF-02367982 Family 2 8
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
Transient receptor potential cation channel subfamily V member... 2 12
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Translocator protein inhibitor SureCN13502542 family 20 2
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 16 2
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Transient receptor potential cation channel subfamily V member... 1 5
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Translocator protein inhibitor AGN-PC-07BUUF family 11 2
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 1 1
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-[1-... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Transient receptor potential cation channel subfamily V member... 6 1
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
C-C chemokine receptor type 2 ligand (E)-1-[4-[2-hydroxy-1-[4-... 2 2
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 4 0
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 18 39
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Gastrin/cholecystokinin type B receptor and Tyrosyl-DNA phosph... 2 10
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Protein kinase C theta type and Tyrosine-protein kinase Lyn in... 2 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 0
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Urokinase-type plasminogen activator and Tissue-type plasminog... 1 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Nischarin inhibitor SureCN7810370 family 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Amine oxidase [flavin-containing] A and Acetylcholinesterase i... 1 2
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1H-indol-6-yl) ace... 2 0
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Transient receptor potential cation channel subfamily V member... 3 2
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
C-X-C chemokine receptor type 2 ligand 4-[5-cyano-2-(4-fluorop... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 4 13
Small conductance calcium-activated potassium channel protein ... 1 1
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 2 2
Caspase-3 and Caspase-7 inhibitor (2S)-N-[(3S)-2-hydroxy-5-oxo... 4 1
Telomerase reverse transcriptase inhibitor N-[9-(4-methoxyanil... 2 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Aldose reductase inhibitor [1-(3,5-difluoro-4-hydroxyphenyl)py... 3 2
Vascular endothelial growth factor receptor 2 ligand (2Z)-2-[[... 1 0
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Sugar Acids and Derivatives Metabolite 6-Hydroxy-5-methoxyindo... 3 1
Indoles Metabolite 6-Methoxy-3-(2-thiazolyl)-1H-indole Family 1 0
Indoles Metabolite Murrastifoline F Family 1 0
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
Putative NP ZINC40309500 Family 4 0
oxo-[4-[(E)-2-(9H-pyrido[3,4-b]indol-1-yl)ethenyl]phenoxy]azan... 1 0
NP N1-(5-bromo-1-ethyl-2-oxoindolin-3-yl)-N2-(2-(5-methoxy-1H-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00050829 DAP000429 Approved Drug Melatonin
CFAMM00049803 CHEMBL109086 Bioactive SureCN9121196
CFAMM00050205 CHEMBL113441 Bioactive SureCN7794006
CFAMM00050509 CHEMBL288084 Bioactive N-[2-(5-methoxy-1H-indol-3-yl)ethyl]butanamide
CFAMM00049647 CHEMBL33700 Bioactive AGN-PC-00FXSW
CFAMM00050142 CHEMBL322762 Bioactive 2,2,2-trifluoro-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
CFAMM00049961 CHEMBL210791 Bioactive AGN-PC-00DARD
CFAMM00049675 CHEMBL34622 Bioactive N-[2-(5-methoxy-1H-indol-3-yl)ethyl]propanamide
CFAMM00050081 CHEMBL37549 Bioactive N-[2-(5-methoxy-1H-indol-3-yl)ethyl]cyclopropanecarboxamide
CFAMM00049716 CHEMBL207960 Bioactive AGN-PC-00D5QS
CFAMM00049761 CHEMBL60719 Bioactive N-[(E)-2-(5-methoxy-1H-indol-3-yl)ethenyl]acetamide
CFAMM00049838 DCL000324 Clinical Trial Drug LY-156735
CFAMM00050677 DNC006640 Investigative Drug beta-methylmelatonin
CFAMM00050758 DNC006639 Investigative Drug beta,beta-dimethylmelatonin
CFAMM00050824 DNC004114 Investigative Drug 2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine
CFAMM00050683 DNC004868 Investigative Drug 5-METHOXYTRYPTAMINE
CFAMM00050397 DNC011274 Investigative Drug (5-methoxy-1H-indol-3-yl)methanamine
CFAMM00049898 DNC005764 Investigative Drug RU-24969
CFAMM00050494 DNC006063 Investigative Drug 5-MEO-DMT
CFAMM00050395 DNC011271 Investigative Drug 6-Fluoromelatonin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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