CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD319
Family Name Penicillin binding protein inhibitor β-lactam aminopenicillin Ampicillin Family
No. of Seeds 12 No. of Other Members 359
Family Centroid CFAMM00051102 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Penicillin binding protein inhibitor β-lactam aminopenicillin ureidopenicillin Superfamily
Class Class 258

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Penicillin binding protein inhibitor β-lactam carbacephem Lora... 1 5
Penicillin binding protein inhibitor β-lactam cephalosporin Ce... 3 38
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 3 1
Penicillin binding protein inhibitor β-lactam ureidopenicillin... 4 9
Atrial natriuretic peptide receptor 1 Ligand Nesiritide Family 6 111
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Angiotensin-converting enzyme Inhibitor Temocapril Family 4 15
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Thymosin Beta-4 family 8 30
Ezatiostat family 1 4
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Renin Inhibitor CP-80794 Family 16 112
Prothrombin Inhibitor Efegatran Family 9 47
Neprilysin Inhibitor Thiorphan Family 41 68
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Gamma-g... 2 1
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Plasmepsin-2 Inhibitor KNI-10232 Family 8 36
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Protein farnesyltransferase subunit beta Inhibitor L-739750 Fa... 4 0
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Pol polyprotein inhibitor 169168-45-0 family 7 11
Pol polyprotein inhibitor 169273-51-2 family 10 0
Pol polyprotein inhibitor penicillin deriv. 49 family 3 19
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Pol polyprotein inhibitor penicillin deriv. 38 family 1 1
Pol polyprotein inhibitor penicillin deriv. 69 family 1 1
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Angiotensin-converting enzyme inhibitor SureCN9749318 family 2 0
Neprilysin inhibitor SureCN489232 family 3 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-5-phenyl... 4 1
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Angiotensin-converting enzyme inhibitor Zofenoprilat family 2 14
Neprilysin inhibitor (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-s... 5 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Pol polyprotein inhibitor Sulfone deriv. 31 family 15 4
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
Angiotensin-converting enzyme inhibitor (2S,4S,5R)-1-[(2R)-2-a... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Glutamate carboxypeptidase 2 inhibitor (2S)-2-[[(1R)-1-carboxy... 8 0
Cathepsin E and Renin inhibitor (2S)-N-[2-[[(2S,3S,5S)-1-cyclo... 4 0
Angiotensin-converting enzyme inhibitor (8S)-7-[2-[hydroxy(4-p... 1 1
Pol polyprotein inhibitor AC1LA4ZN family 1 1
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1
Angiotensin-converting enzyme and Histone-lysine N-methyltrans... 1 19
Pol polyprotein inhibitor AC1LACBC family 2 0
Angiotensin-converting enzyme and Neprilysin inhibitor (5R,7S)... 1 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Angiotensin-converting enzyme and Leukotriene A-4 hydrolase in... 7 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Neprilysin inhibitor AGN-PC-02K4O6 family 2 0
Neprilysin inhibitor methyl (2S)-4-methyl-2-[[2-(sulfanylmethy... 3 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 1 5
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Histone deacetylase 8 and Histone deacetylase 1 inhibitor tert... 1 0
Caspase-3 and Caspase-7 inhibitor valine aspartyl ketone 16 fa... 3 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 3
Capsid scaffolding protein inhibitor 2-[(2S)-2-[[(2S)-2-(3,3-d... 1 3
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 2 0
Angiotensin-converting enzyme inhibitor (2S)-1-[2-(1-ethoxy-1-... 1 0
Gag-Pro polyprotein inhibitor (4S)-3-[(2S,3S)-3-[[(2S,3S)-2-[[... 4 0
Tubulin beta-1 chain inhibitor SureCN6672529 family 1 0
NP Methyl 5-((2s,3s,4r)-4-benzamido-3-chlorotetrahydrothiophen... 4 0
(2S)-2-[(3aR,6aS)-2,5-dioxo-3,3a,6,6a-tetrahydro-1H-imidazo[4,... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00051051 DAP001168 Approved Drug Penicillin G
CFAMM00050943 DAP001314 Approved Drug Benzylpenicilloyl Polylysine
CFAMM00051103 DAP000438 Approved Drug Carbenicillin
CFAMM00051102 DAP000432 Approved Drug Ampicillin
CFAMM00051209 DNAP001482 Approved Drug Alacepril
CFAMM00051117 CHEMBL322266 Bioactive AGN-PC-00LNFC
CFAMM00050947 CHEMBL347755 Bioactive SureCN10727055
CFAMM00050994 CHEMBL340528 Bioactive (3R,6S)-6-[(1-carboxy-3-phenylpropyl)amino]-5-oxo-3,6,7,8,9,9a-hexahydro-2H-[1,3]thiazolo[3,2-a]azepine-3-carboxylic acid
CFAMM00050946 CHEMBL312224 Bioactive (3R,9aR)-6-[(1-carboxy-3-phenylpropyl)amino]-5-oxo-3,6,7,8,9,9a-hexahydro-2H-[1,3]thiazolo[3,2-a]azepine-3-carboxylic acid
CFAMM00051012 CHEMBL351614 Bioactive (3R,6S,9aR)-6-[[(2S)-2-benzyl-3-sulfanylpropanoyl]amino]-5-oxo-3,6,7,8,9,9a-hexahydro-2H-[1,3]thiazolo[3,2-a]azepine-3-carboxylic acid
CFAMM00050930 DNC001109 Investigative Drug Penicillin
CFAMM00051170 DNC000302 Investigative Drug Benzylpenicillin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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