CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD336
Family Name Retinoic acid receptor alpha Ligand Tamibarotene Family
No. of Seeds 5 No. of Other Members 95
Family Centroid CFAMM00051644 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Retinoic acid receptor alpha Ligand Tamibarotene Superfamily
Class Class 271

Cousin Family NamesSeedsMembers
Sodium channel protein type 10 subunit alpha Ligand Tetracaine... 6 166
Prostaglandin G/H synthase 1 Inhibitor Mesalazine Family 2 30
Prostaglandin G/H synthase 2 Inhibitor Mefenamic Acid Family 7 137
Cyclooxygenase Inhibitor Meclofenamic Acid Family 4 11
Serum albumin Inhibitor Iodipamide Family 2 23
Histamine H1 receptor Ligand Tranilast Family 5 125
Histone deacetylase 1 and Tyrosine-protein kinase JAK2 Inhibit... 2 3
Intedanib family 7 54
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
New permeability pathways Inhibitor 5-nitro-2-(3-phenylpropyla... 1 13
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Neuraminidase Inhibitor 4-(acetylamino)-3-amino Benzoic Acid F... 2 27
Tyrosine-protein phosphatase non-receptor type 1 Ligand 2-(oxa... 3 11
Dihydroorotate dehydrogenase Inhibitor 2-(2-bromo-2-naphthamid... 1 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2 Inhibitor 4-[4-(benzyl... 2 19
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Transient receptor potential cation channel subfamily V member... 2 29
Bifunctional epoxide hydrolase 2 Inhibitor 4-(3-adamantan-1-yl... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 2-hydroxy-n,6-bis(... 2 7
Acetylcholinesterase Inhibitor 3-(2,5-dioxo-pyrrolidin-1-yl)-b... 2 4
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 8
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 6 13
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[7-[[4-(N'-... 7 15
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7345980... 4 6
Protease inhibitor AC1LALME family 2 1
Retinal dehydrogenase 1 and Menin inhibitor CHEMBL1507858 family 1 6
Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family 10 3
Free fatty acid receptor 1 ligand AGN-PC-03ZC6J family 2 14
Diacylglycerol O-acyltransferase 1 inhibitor Urea-based Analog... 7 5
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Glucocorticoid receptor and Progesterone receptor ligand AGN-P... 2 9
Bifunctional epoxide hydrolase 2 inhibitor 6-[[1-(2,4-dimethyl... 1 3
Mitogen-activated protein kinase 14 inhibitor ethyl 3-(2,4-dif... 5 1
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C8 liga... 2 0
Collagenase 3 inhibitor 4-[[4-oxo-6-(3-phenylprop-1-ynyl)quina... 2 9
Integrin beta-3 and Integrin alpha-V inhibitor SureCN7494201 f... 5 14
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 4 7
Coagulation factor X and Tissue factor inhibitor AGN-PC-02WN8Y... 7 22
Glycogen phosphorylase, liver form inhibitor AGN-PC-00CDLB family 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 2
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-0BOW0P... 1 0
Retinoic acid receptor RXR-beta and Retinoic acid receptor RXR... 1 0
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 7 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[1... 2 5
Tankyrase-2 inhibitor 3-chloro-4-(4-methyl-2-oxo-1H-quinolin-7... 1 2
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 7 6
ATP-sensitive inward rectifier potassium channel 11 ligand 3-c... 2 4
Protein farnesyltransferase subunit beta and Protein farnesylt... 2 4
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 2 11
Retinal dehydrogenase 1 and ATP-dependent DNA helicase Q1 inhi... 1 1
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 1 2
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 1
Glucocorticoid receptor ligand AGN-PC-01X8JJ family 1 0
2-oxo-1H-quinoline-4-carboxylate NP ZINC19735150 Family 5 4
Putative NP ZINC12659473 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00051644 DAP000461 Approved Drug Tamibarotene
CFAMM00051571 DNC006007 Investigative Drug 2-(2-naphthamido)benzoic acid
CFAMM00051565 DNC003391 Investigative Drug 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid
CFAMM00051640 DNC007887 Investigative Drug 2-(3-(naphthalen-2-yl)propanamido)benzoic acid
CFAMM00051575 DNC006087 Investigative Drug 4-[4-(benzoylamino)benzoyl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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