CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Serotonin re-uptake Inhibitor Paroxetine Family
No. of Seeds 6 No. of Other Members 19
Family Centroid CFAMM00051714 Functional Category Approved Drug
Superfamily Serotonin re-uptake Inhibitor Paroxetine Superfamily
Class Class 273

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2


External ID

Functional Category

Molecule Name

CFAMM00051714 DAP000463 Approved Drug Paroxetine
CFAMM00051715 CHEMBL151140 Bioactive 3-[1,3-benzodioxol-5-yloxy-(4-fluorophenyl)methyl]piperidine
CFAMM00051697 CHEMBL1628650 Bioactive [3H]-Paroxetine
CFAMM00051713 CHEMBL606881 Bioactive (1R,3R,4S)-4-(1,3-benzodioxol-5-yloxymethyl)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane
CFAMM00051694 CHEMBL1708 Bioactive Paroxetine hydrochloride
CFAMM00051716 CHEMBL88301 Bioactive (3R,4S)-4-(1,3-benzodioxol-5-yloxymethyl)-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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