CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD342
Family Name Thromboxane A2 receptor Ligand Ridogrel Family
No. of Seeds 7 No. of Other Members 83
Family Centroid CFAMM00051813 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Thromboxane A2 receptor Ligand Ridogrel Superfamily
Class Class 277

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Farnesyl pyrophosphate synthase Inhibitor Risedronate Family 4 28
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Diacylglycerol O-acyltransferase 2 and Hydroxycarboxylic acid ... 4 45
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Coagulation factor X Inhibitor Otamixaban Family 9 21
Potassium-competitive acid Inhibitor TAK-438 Family 2 8
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
FK506-binding protein 1A Inhibitor Gpi-1046 Family 4 10
Aromatase Inhibitor Rogletimide Family 1 2
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor Cycl... 1 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 2 24
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 2 1
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 4 8
C-C chemokine receptor type 5 ligand AC1LA259 family 1 1
Sterol O-acyltransferase 1 inhibitor dodecyl 3-[2,6-di(propan-... 1 2
Pol polyprotein inhibitor AGN-PC-0AAOIM family 4 0
Thromboxane A2 receptor and Thromboxane-A synthase ligand (E)-... 2 0
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 3 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
Progesterone receptor ligand (8S,11R,13S,14S,16R,17S)-17-(cycl... 11 0
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Thromboxane-A synthase inhibitor (Z)-2-bromo-3-[4-(pyridin-3-y... 1 0
Free fatty acid receptor 1 ligand 3-[4-[2-(7-chloroquinolin-4-... 1 0
Free fatty acid receptor 1 ligand 3-[4-[2-(2,6-dichloro-3-meth... 3 0
Thromboxane-A synthase inhibitor SureCN9825871 family 6 3
Prelamin-A/C and Excitatory amino acid transporter 1 inhibitor... 1 0
Cytochrome P450 2C19 inhibitor AGN-PC-07CPMJ family 1 0
Aromatase and Steroid 17-alpha-hydroxylase/17,20 lyase inhibit... 1 0
Receptor-type tyrosine-protein phosphatase beta ligand AGN-PC-... 1 2
Potassium voltage-gated channel subfamily A member 5 ligand AG... 4 0
Fatty-acid amide hydrolase 1 inhibitor [(1R)-1-[(3S)-2-oxo-1-p... 1 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-[[2-[3... 4 0
Amino Acids and Derivatives Metabolite Allodesmosine Family 2 0
Pyridines and Derivatives Metabolite 4-Hydroxy-4-(3-pyridyl)-b... 1 2
Pyridines and Derivatives Metabolite Rotundine A Family 1 0
heptanamide NP ZINC08740384 Family 7 0
NP 2-methyl-5-(2-(pyridin-3-yl)piperidin-1-yl)pent-3-yn-2-yl A... 8 1
NP (2-methyl-5-(prop-1-en-2-yl)cyclopent-1-en-1-yl)methyl Ison... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00051813 DAP000469 Approved Drug Ridogrel
CFAMM00051838 CHEMBL165575 Bioactive ethyl 5-[(E)-[phenyl(pyridin-3-yl)methylidene]amino]oxypentanoate
CFAMM00051804 CHEMBL129867 Bioactive 5-[(E)-[pyrazin-2-yl-[3-(trifluoromethyl)phenyl]methylidene]amino]oxypentanoic acid
CFAMM00051778 CHEMBL28196 Bioactive AC1O6WLB
CFAMM00051821 CHEMBL299224 Bioactive 5-[(Z)-[pyridin-4-yl-[3-(trifluoromethyl)phenyl]methylidene]amino]oxypentanoic acid
CFAMM00051767 CHEMBL117233 Bioactive ethyl 5-[(Z)-[phenyl(pyridin-3-yl)methylidene]amino]oxypentanoate
CFAMM00051759 CHEMBL26820 Bioactive Isbogrel

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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