CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD344
Family Name Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family
No. of Seeds 4 No. of Other Members 36
Family Centroid CFAMM00051943 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily biogenic amine receptor, Tyrosine metabolism enzyme binding L-Tyrosine derivative Superfamily
Class Class 163

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha adrenergic receptor ligand L-Tyrosine derivative Methyld... 2 3
Oxytocin receptor Ligand Oxytocin Family 30 182
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Family 19 144
Oestrogen receptor ligand Dienestrol Family 35 440
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Thymopentin family 20 133
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Kynureninase Inhibitor 3-hydroxyhippuric Acid Family 1 9
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Sodium-dependent dopamine transporter inhibitor AC1MIIGH family 2 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 2
Aminopeptidase N and Cytosol aminopeptidase inhibitor AGN-PC-0... 1 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Alpha-1D adrenergic receptor ligand AGN-PC-0761MO family 1 0
Glutamate carboxypeptidase 2 inhibitor 2-[(3-hydroxyphenyl)met... 1 0
Neuropeptide S receptor and Metabotropic glutamate receptor 1 ... 1 2
Tyrosine-protein phosphatase non-receptor type 1 ligand FLUORO... 1 1
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor (-)-xyla... 3 1
Carbonic anhydrase 2 and Carbonic anhydrase inhibitor N-tert-b... 2 2
Amino Acids and Derivatives Metabolite 3-Nitrotyrosine Family 1 3
Phenethylamines Metabolite Tyramine-O-sulfate Family 1 1
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1
(2R,3S)-2-(benzenesulfonamido)-3-hydroxy-3-phenylpropanoate NP... 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00051962 DAP000471 Approved Drug Metyrosine
CFAMM00051943 DAP000808 Approved Drug L-Tyrosine
CFAMM00051964 DAP001315 Approved Drug Glatiramer Acetate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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