CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Beta-1 adrenergic receptor Ligand Oxprenolol Family
No. of Seeds 3 No. of Other Members 27
Family Centroid CFAMM00052247 Functional Category Approved Drug with Natural Product
Superfamily Beta-1 adrenergic receptor Ligand Oxprenolol Superfamily
Class Class 282

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor M2 Ligand Gallamine Triethio... 1 14
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Alpha-2 adrenergic receptor Ligand Idazoxan Family 6 26
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Potassium voltage-gated channel subfamily H member 2 Ligand Al... 2 3
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Beta-3 adrenergic receptor Ligand ZD7114 Family 1 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 8
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Survival motor neuron protein and Lysine-specific demethylase ... 1 16
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 5
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Neuronal acetylcholine receptor subunit alpha-10 ligand (2S)-2... 1 0
Squalene synthase inhibitor [4-[3-(propan-2-ylamino)propoxy]ph... 1 3
Sigma non-opioid intracellular receptor 1 ligand SureCN7450653... 1 0
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 2
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 3
Beta-lactamase inhibitor CHEMBL1566697 family 1 5


External ID

Functional Category

Molecule Name

CFAMM00052247 DAP000485 Approved Drug Oxprenolol
CFAMM00052224 DNC008727 Investigative Drug 2-((2-ethoxyphenoxy)methyl)-4-isopropylmorpholine
CFAMM00052252 DNC004882 Investigative Drug (2-hydroxy-3-phenoxypropyl)(propan-2-yl)amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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