CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name DNA polymerase inhibitor guanosine analog Aciclovir Family
No. of Seeds 4 No. of Other Members 41
Family Centroid CFAMM00052292 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily DNA polymerase inhibitor guanosine analog Aciclovir Didanosine Superfamily
Class Class 283

Cousin Family NamesSeedsMembers
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor xant... 18 210
Tumor necrosis factor inhibitor xanthine derivative Pentoxifyl... 5 69
xanthine alkaloid Theobromine family 6 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor xant... 3 7
DNA polymerase Inhibitor Valaciclovir Family 2 0
HIV reverse transcriptase inhibitor guanosine analog Didanosin... 20 166
Inosine-5'-monophosphate dehydrogenase Inhibitor Mizoribine Fa... 1 0
Purine nucleoside phosphorylase Inhibitor 9-(5,5-difluoro-5-ph... 1 16
Purine nucleoside phosphorylase Inhibitor 8-iodo-guanine Family 2 3
Hypoxanthine-guanine-xanthine phosphoribosyltransferase Inhibi... 3 7
Purine nucleoside phosphorylase inhibitor [(3R,4S)-3-(2-amino-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00052288 DAP000488 Approved Drug Penciclovir
CFAMM00052292 DAP000816 Approved Drug Aciclovir
CFAMM00052347 DAP000645 Approved Drug Ganciclovir
CFAMM00052300 DNC000437 Investigative Drug Cis-[PtCl(NH3)2(N7-acyclovir)]+

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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