CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD354
Family Name Histamine H1 receptor Ligand Diphenhydramine Family
No. of Seeds 5 No. of Other Members 75
Family Centroid CFAMM00052415 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Biogenic amine receptor Diphenhydramine Phendimetrazine Diphenylpyraline Superfamily
Class Class 231

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Histamine H1 receptor Ligand Clemastine Family 5 76
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Pitolisant family 4 24
Dapoxetine family 3 40
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-076TWX... 8 5
Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4
Substance-P receptor ligand SureCN8112982 family 1 0
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 0
Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 1 2
Substance-P receptor ligand SureCN8415737 family 3 4
Sigma non-opioid intracellular receptor 1 ligand SureCN7425449... 2 0
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Substance-P receptor ligand SureCN8912140 family 2 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0
Histamine H1 receptor and 5-hydroxytryptamine receptor 2A liga... 1 0
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 2 14
Cathepsin K and Cathepsin L1 inhibitor 3-(phenylmethoxymethyl)... 1 0
Acenes Metabolite Naphthalene epoxide Family 3 49
Benzyloxycarbonyls Metabolite Benzyl acetate Family 5 53
2-methyl-6-phenyl-5-prop-1-en-2-yloxane-2-carbonitrile NP ZINC... 8 11
4-benzylidene-6-phenyl-1,2,3,6,6a,7,8,9-octahydrobenzo[c]chrom... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00052401 DAP001072 Approved Drug Bromodiphenhydramine
CFAMM00052437 DAP000858 Approved Drug Orphenadrine
CFAMM00052415 DAP000490 Approved Drug Diphenhydramine
CFAMM00052388 CHEMBL609131 Bioactive N,N-dimethyl-2-[(R)-(4-methylphenyl)-phenylmethoxy]ethanamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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