CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Duloxetine Family
No. of Seeds 8 No. of Other Members 6
Family Centroid CFAMM00052549 Functional Category Approved Drug
Superfamily Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Duloxetine Superfamily
Class Class 286

Cousin Family NamesSeedsMembers
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
D(2) dopamine receptor Ligand N-0923 Family 6 41
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Leukotriene A-4 hydrolase inhibitor SureCN2108222 family 3 9
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 13


External ID

Functional Category

Molecule Name

CFAMM00052549 DAP000494 Approved Drug Duloxetine
CFAMM00052537 CHEMBL553224 Bioactive N-methyl-1-[(1S,2S)-2-naphthalen-1-yloxy-2-thiophen-2-ylcyclopropyl]methanamine;hydrochloride
CFAMM00052534 CHEMBL424660 Bioactive CHEBI:36796
CFAMM00052533 CHEMBL142028 Bioactive AGN-PC-00HJOO
CFAMM00052539 CHEMBL558329 Bioactive N-methyl-1-[(1R,2S)-2-naphthalen-1-yloxy-2-thiophen-2-ylcyclopropyl]methanamine;hydrochloride
CFAMM00052536 DNC006814 Investigative Drug (R)-DULOXETINE
CFAMM00052542 DNC010244 Investigative Drug (S)-NORDULOXETINE
CFAMM00052540 DNC010243 Investigative Drug R-NORDULOXETINE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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