CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD36
Family Name Alpha-1 adrenergic receptor ligand arylethanolamine derivative Labetalol family
No. of Seeds 4 No. of Other Members 37
Family Centroid CFAMM00007552 Functional Category Approved Drug
Superfamily Alpha-1 adrenergic receptor ligand arylethanolamine derivative Labetalol Superfamily
Class Class 36

Cousin Family NamesSeedsMembers
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Thymopentin family 20 133
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-isopropyl Estrad... 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Tyrosinase Inhibitor N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenz... 3 2
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 20 7
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 5 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 3 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Pol polyprotein inhibitor AC1LA3AI family 5 9
Pol polyprotein inhibitor 168912-67-2 family 1 0
Coagulation factor X inhibitor 3-[4-[[(E)-3-[3-(diaminomethyli... 4 6
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 16 2
Pol polyprotein inhibitor AC1LA3CC family 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 9
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 7
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
Putative NP ZINC08790868 Family 10 0
NP 2-((5-hydroxy-2,2-dimethyl-4-oxochroman-7-yl)oxy)-n-(3-meth... 18 0
NP 2-((1'-acetyl-4-oxospiro[chroman-2,4'-piperidin]-7-yl)oxy)-... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00007552 DAP000038 Approved Drug Labetalol
CFAMM00007539 CHEMBL1200323 Bioactive Labetalol hydrochloride
CFAMM00007560 CHEMBL230487 Bioactive SureCN4260722
CFAMM00007558 CHEMBL2051964 Bioactive 2-hydroxy-N-[[(1S,5R)-5-hydroxy-1,3,3-trimethylcyclohexyl]methyl]-5-methylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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