CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD368
Family Name Sodium channel protein type 5 subunit alpha Ligand Hexylcaine Family
No. of Seeds 4 No. of Other Members 94
Family Centroid CFAMM00053320 Functional Category Approved Drug with Natural Product
Superfamily Sodium channel protein type 5 subunit alpha Ligand Hexylcaine Superfamily
Class Class 296

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Muscarinic acetylcholine receptor Ligand Mepenzolate Family 35 11
Muscarinic acetylcholine receptor M1 Ligand Oxyphenonium Family 12 5
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Flovagatran family 12 546
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 1 6
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor [(1R)-1-(... 2 5
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Peptidyl-prolyl cis-trans isomerase FKBP1A and Peptidyl-prolyl... 4 27
Sigma non-opioid intracellular receptor 1 ligand SureCN5315520... 3 11
5-hydroxytryptamine receptor 1A ligand SureCN7763400 family 4 9
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-04TFA0... 1 0
Sodium-dependent dopamine transporter inhibitor (1R,3S)-3-(4-a... 1 0
Sodium-dependent dopamine transporter and Transporter inhibito... 1 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 9 14
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Beta-3 adrenergic receptor ligand SureCN4584432 family 5 2
Sodium-dependent serotonin transporter and Transporter inhibit... 2 4
Neprilysin inhibitor benzyl (2S)-2-[[2-(sulfanylmethyl)-3,4-di... 4 0
Histamine H1 receptor and 5-hydroxytryptamine receptor 2C liga... 1 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 3
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 7 1
Beta-3 adrenergic receptor ligand SureCN4583819 family 5 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (4aR,... 1 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 10
Extracellular calcium-sensing receptor ligand SureCN4609584 fa... 7 8
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 0
Acetylcholine-binding protein and Soluble acetylcholine recept... 1 2
ATP-sensitive inward rectifier potassium channel 1 and Potassi... 3 3
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 1-... 1 0
Huntingtin and Inositol monophosphatase 1 inhibitor CHEMBL1493... 1 1
N-[[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-methylcarbamothioyl... 1 0
[(3S,4R)-4-benzoyloxythiolan-3-yl]azanium NP ZINC04061904 Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00053320 DAP000506 Approved Drug Hexylcaine
CFAMM00053345 DNC007452 Investigative Drug 4-[4-(benzyloxy)piperidino]butyl benzoate
CFAMM00053357 DNC000345 Investigative Drug BRL 26830A
CFAMM00053356 DNC003654 Investigative Drug Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543