CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD371
Family Name Sodium channel protein type 5 subunit alpha Ligand Dyclonine Family
No. of Seeds 6 No. of Other Members 174
Family Centroid CFAMM00053717 Functional Category Approved Drug with Natural Product
Superfamily Sodium channel protein type 5 subunit alpha Ligand Dyclonine Superfamily
Class Class 298

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Peroxisome proliferator-activated receptor alpha Ligand Fenofi... 3 127
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Potassium voltage-gated channel subfamily H member 2 Ligand Am... 2 16
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Muscarinic acetylcholine receptor Ligand Mebeverine Family 2 27
Ipriflavone family 62 2480
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Histamine H3 receptor Ligand A-317920 Family 9 240
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxy-4-(4-methoxy-phen... 6 4
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 0
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Amine oxidase [flavin-containing] B inhibitor 5-(4,4,4-trifluo... 2 9
Histamine H1 receptor ligand Ahr 5333 family 1 6
Histamine H3 receptor ligand SureCN2784769 family 12 2
Sigma non-opioid intracellular receptor 1 and Vesicular acetyl... 3 7
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Histamine H3 receptor ligand SureCN7244264 family 1 0
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Acetylcholinesterase and Butyrylcholinesterase inhibitor 2-[4-... 3 2
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 12
Sterol 26-hydroxylase, mitochondrial and 1,25-dihydroxyvitamin... 1 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 7
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 1
Lanosterol synthase inhibitor AC1L9UWE family 1 0
Squalene--hopene cyclase and Lanosterol synthase inhibitor R17... 1 22
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-[1-(adaman... 1 0
Collagenase 3 inhibitor ethyl 4-[4-[2-[(3S)-3-hydroxy-1-azabic... 1 0
Multidrug resistance protein 1 inhibitor 1-[4-[(2R)-2-hydroxy-... 1 0
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 0
Thyroid hormone receptor beta ligand 3-(4-acetylpiperazin-1-yl... 3 2
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 11
Benzofurans Metabolite (R)-Bitalin A Family 1 9
oxybenzoate NP ZINC04029407 Family 4 1
methoxybenzoate NP ZINC04028167 Family 2 0
1-benzofuran-3-one NP ZINC09486173 Family 33 0
NP Agn-pc-054n5h Family 5 0
Putative NP ZINC20357755 Family 11 0
2-(trifluoromethyl)chromen-4-one NP ZINC02418160 Family 7 0
6-hydroxy-7-(morpholin-4-ylmethyl)-1-benzofuran-3-one NP ZINC2... 7 0
NP 7-[(4-bromobenzyl)oxy]-3-(2-methoxyphenyl)-2-(trifluorometh... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00053717 DAP000509 Approved Drug Dyclonine
CFAMM00053841 CHEMBL114259 Bioactive (4-bromophenyl)-[4-[6-[methyl(prop-2-enyl)amino]hexoxy]phenyl]methanone;(E)-but-2-enedioic acid
CFAMM00053708 CHEMBL554209 Bioactive AGN-PC-07BZTN
CFAMM00053808 CHEMBL416694 Bioactive SureCN2131185
CFAMM00053668 DNC009792 Investigative Drug 1-(4-(Hexyloxy)phenyl)-3-morpholinopropan-1-one
CFAMM00053784 DNC001226 Investigative Drug Ro48-8071

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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