CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD374
Family Name Sodium channel protein type 5 subunit alpha Ligand Procainamide Family
No. of Seeds 7 No. of Other Members 291
Family Centroid CFAMM00054294 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Sodium channel protein type 5 subunit alpha Ligand Procainamide Superfamily
Class Class 301

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Cholesterol side-chain cleavage enzyme, mitochondrial and Arom... 9 26
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
DNA Binder Procarbazine Family 8 358
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Androgen receptor Ligand Enzalutamide Family 1 4
Motilin receptor Ligand GSK962040 Family 30 457
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Bavisant family 9 65
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 18
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Proto-oncogene tyrosine-protein kinase Src Inhibitor ISO24 Family 3 9
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Transient receptor potential cation channel subfamily V member... 6 33
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Histone deacetylase 2 Inhibitor N-(4-amino-4'-bromobiphenyl-3-... 1 1
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Vasopressin V1a receptor ligand AGN-PC-074VSA family 3 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7345980... 4 6
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Peptide deformylase inhibitor (2R)-2-[[formyl(hydroxy)amino]me... 2 1
Peptide deformylase inhibitor (2R)-2-(cyclopentylmethyl)-3-[fo... 11 2
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Amyloid beta A4 protein inhibitor AGN-PC-08WTQK family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 1 1
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Histamine H3 receptor ligand SureCN3058680 family 4 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Transient receptor potential cation channel subfamily V member... 1 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 11 9
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Urokinase plasminogen activator surface receptor ligand 5,12-d... 1 0
Mitogen-activated protein kinase 14 inhibitor 3-(3-benzamido-4... 2 0
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Histone deacetylase 1 inhibitor SureCN3642893 family 10 23
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Dipeptidyl peptidase 4 inhibitor 4-[4-[(3S,5S)-5-(1,3-thiazoli... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 1
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Cathepsin K and Cathepsin B inhibitor AGN-PC-076LFZ family 1 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
Acetylcholinesterase inhibitor tmtfa family 1 2
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-[(4-nitrobenz... 1 1
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Beta-lactamase inhibitor (1R,5S)-4-[(4-carbamoylphenyl)carbamo... 3 2
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Amyloid beta A4 protein inhibitor (2S,3R)-3-(2-methylpropyl)-N... 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 1 2
Proteinase-activated receptor 1 ligand 2-bromo-N-[3-(butanoyla... 4 0
Glutathione reductase, mitochondrial inhibitor (S)-2-(4-Nitrob... 1 3
D-alanyl-D-alanine carboxypeptidase and Penicillin-binding pro... 1 0
Polymerase acidic protein inhibitor (Z)-4-hydroxy-2-oxo-4-(4-p... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 1 0
Lysophosphatidic acid receptor 3 and Microtubule-associated pr... 1 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854179 f... 1 0
1,3,3a,5-tetrahydro-[1,3]thiazolo[4,3-c][1,4]benzodiazepine-4,... 3 1
NP (s)-methyl 2-(3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1... 11 3
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3
Putative NP ZINC32124058 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00054294 DAP000516 Approved Drug Procainamide
CFAMM00054021 CHEMBL1256805 Bioactive Acecainide hydrochloride
CFAMM00054033 CHEMBL605 Bioactive procainamide hydrochloride
CFAMM00054075 CHEMBL198859 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(dimethylamino)benzamide
CFAMM00054215 DCL001122 Clinical Trial Drug Tacedinaline
CFAMM00053993 DCL000714 Clinical Trial Drug Balicatib
CFAMM00054035 DNC000146 Investigative Drug Acetylprocainamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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