CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD375
Family Name Sodium channel protein type 5 subunit alpha Ligand Flecainide Family
No. of Seeds 2 No. of Other Members 162
Family Centroid CFAMM00054382 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Sodium channel protein type 5 subunit alpha Ligand Flecainide Superfamily
Class Class 302

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Sulpiride Family 7 38
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 3A Ligand KB-6806 Family 12 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Amine oxidase [flavin-containing] B Inhibitor N-isobutyl-2-oxo... 4 8
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Histone deacetylase 1 Inhibitor N-hydroxy-8-(2-methoxyphenyl)-... 2 14
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (2R)-2-(benze... 4 13
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 10
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Prothrombin inhibitor AGN-PC-09QMX5 family 2 3
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
Pol polyprotein inhibitor MDL 74538 family 11 1
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Motilin receptor ligand SureCN74051 family 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Scytalone dehydratase inhibitor AGN-PC-074L4J family 1 0
Histamine H1 receptor ligand SureCN7952197 family 1 0
Histone deacetylase 3 and Histone deacetylase 6 inhibitor (E)-... 1 1
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
Calpain-1 catalytic subunit inhibitor (3S)-3-[[4-[2-(methoxyme... 2 4
Sodium channel protein type 1 subunit alpha and Sodium channel... 2 0
Putative NP ZINC02127056 Family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00054382 DAP000518 Approved Drug Flecainide
CFAMM00054437 CHEMBL91379 Bioactive N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3-dihydro-1-benzofuran-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543