CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD376
Family Name Sodium channel protein type 5 subunit alpha Ligand Encainide Family
No. of Seeds 4 No. of Other Members 248
Family Centroid CFAMM00054851 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Sodium channel protein type 5 subunit alpha Ligand Encainide Superfamily
Class Class 303

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand quinolone derivative Carteolol... 1 38
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
Sodium channel protein type 5 subunit alpha Ligand Proparacain... 2 26
Histamine H1 receptor Ligand Tranilast Family 5 125
Zucapsacin family 7 177
Stromelysin-1 Inhibitor PG-530742 Family 4 23
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
Darexaban Maleate family 1 13
Cinitapride family 4 22
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
High affinity nerve growth factor receptor and RAF proto-oncog... 3 29
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Liver carboxylesterase 1 Inhibitor 5-(trifluoromethoxy)-1h-ind... 3 12
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Urotensin-2 receptor Ligand SB-436811 Family 6 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Amine oxidase [flavin-containing] A and Mitogen-activated prot... 1 71
Oxytocin receptor and Vasopressin V1a receptor Ligand L-372662... 31 23
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxy-phenyl)-... 1 3
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Lanosterol synthase inhibitor SureCN7685733 family 1 3
Poly [ADP-ribose] polymerase 1 inhibitor 6-[1-(2,3-dihydro-1,4... 1 30
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin E2 receptor EP4 subtype ligand SureCN3581203 family 1 0
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Trace amine-associated receptor 1 ligand EPPTB family 4 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Histamine H3 receptor ligand SureCN2785624 family 2 0
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Substance-P receptor ligand 1-[(5-amino-2-methoxyphenyl)methyl... 3 5
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 2 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Adenosine receptor A3 and Adenosine receptor A1 ligand 4-metho... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 3
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Oxytocin receptor ligand SureCN8092936 family 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 2
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Retinoic acid receptor RXR-gamma and Retinoic acid receptor RX... 3 36
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Trace amine-associated receptor 1 ligand ZINC07609882 family 2 0
Leukotriene B4 receptor 1 ligand 4-methoxy-3-[[(E)-3-(4-phenyl... 2 10
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32423... 1 0
Metabotropic glutamate receptor 2 ligand AGN-PC-03PQDX family 5 1
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Major prion protein and Microtubule-associated protein tau inh... 2 10
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Beta-lactamase and 4'-phosphopantetheinyl transferase ffp inhi... 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN6679437 fa... 1 0
Cytochrome P450 2D6 inhibitor 2-[(3-butoxyphenoxy)methyl]-3-me... 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 3 0
Coagulation factor X inhibitor 3,4-dimethoxy-N-[N-(4-methoxyph... 3 0
ATP-sensitive inward rectifier potassium channel 11 ligand AGN... 2 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Beta-lactamase and Microtubule-associated protein tau inhibito... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Putative NP ZINC04030010 Family 8 3
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0
dimethyl 5-[[2-(3,4,7,8,9,10-hexahydro-2H-[1,4]dioxepino[2,3-g... 1 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
2-(1'-acetyl-4-oxospiro[3H-chromene-2,4'-piperidine]-7-yl)oxya... 5 1
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
3-[(3-amino-4-methoxybenzoyl)amino]propanoate NP Agn-pc-09e1h5... 1 1
3,5-bis[[2-(4-methoxyphenoxy)acetyl]amino]benzoate NP Agn-pc-0... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00054851 DAP000519 Approved Drug Encainide
CFAMM00054787 DNC007861 Investigative Drug N-(2-aminophenyl)-4-methoxybenzamide
CFAMM00054697 DNC008117 Investigative Drug N-(4-iodophenyl)-4-(trifluoromethoxy)benzamide
CFAMM00054690 DNC000665 Investigative Drug Fuscoside

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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