CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD395
Family Name Aldehyde oxidase inhibitor para-naphthoquinone Menadione Family
No. of Seeds 22 No. of Other Members 503
Family Centroid CFAMM00055812 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Aldehyde oxidase inhibitor Menadione Vitamin K epoxide reductase inhibitor Phenindione Superfamily
Class Class 320

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
Vitamin K epoxide reductase complex subunit 1 Inhibitor Phenin... 5 44
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
DNA topoisomerase 1 Inhibitor Beta-lapachone Family 3 66
Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Family 4 13
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Cathepsin G Inhibitor Bis-napthyl Beta-ketophosphonic Acid Family 1 3
Cathepsin L1 Inhibitor Biphenyl-4-yl-acetaldehyde Family 2 86
Cytosolic phospholipase A2 Inhibitor 1,1,1,2,2-pentafluoro-8-p... 11 18
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,3,6-trifluorophen... 16 11
Liver carboxylesterase 1 Inhibitor 1-(4-chloro-phenyl)-2-pheny... 5 47
Liver carboxylesterase 1 Inhibitor 1,2-bis-(4-bromo-phenyl)-et... 2 26
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(p... 3 54
Glutathione reductase, mitochondrial and Trypanothione reducta... 2 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 8
Liver carboxylesterase 1 Inhibitor Acenanthrene-9,10-dione Family 2 12
M-phase inducer phosphatase 1 and M-phase inducer phosphatase ... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-phe... 6 23
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-methoxy-1,4-naphthoq... 1 3
Histone deacetylase 1 Inhibitor N-hydroxy-6-oxo-6-phenylhexana... 7 7
Histone deacetylase 1 Inhibitor N-hydroxy-7-(naphthalen-2-yl)-... 3 2
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(naphth... 1 3
4-hydroxyphenylpyruvate dioxygenase Inhibitor 2-(2-iodo-benzoy... 3 1
Neuraminidase Inhibitor (e,e)-1,7-diphenyl-4,6-heptadien-3-one... 2 5
Histone deacetylase 2 and Histone deacetylase 8 inhibitor 2-hy... 1 1
Aromatase inhibitor (6R)-6-benzyl-10,13-dimethyl-2,6,7,8,9,11,... 1 29
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 13
RAC-alpha serine/threonine-protein kinase inhibitor CHEMBL4754... 2 17
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 1 0
Kinesin-like protein KIF11 inhibitor 1-[4-[2-aminoethylsulfany... 2 4
Progesterone receptor ligand AGN-PC-07COX3 family 1 4
Thyrotropin receptor and Retinal dehydrogenase 1 ligand NINHYD... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 1
Glycogen synthase kinase-3 beta inhibitor 3-(2,2-dibromoacetyl... 1 0
Cocaine esterase and Liver carboxylesterase 1 inhibitor 1-brom... 1 1
Integrase inhibitor AGN-PC-00QHSA family 1 2
Acenes Metabolite Dithianon Family 1 1
Prenol Lipids Metabolite 11,12-Dihydrolactaroviolin Family 2 2
Indanes Metabolite Pterosin F Family 1 1
Prenol Lipids Metabolite Myrigalone A Family 1 1
1-oxoisothiochromene-3-carboxylate NP ZINC00079372 Family 2 0
2-[(2,4-dichlorophenyl)methylidene]-4,4,6,6-tetramethylbicyclo... 6 1
NP 4-methoxydalbergione Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00055812 DAP000544 Approved Drug Menadione
CFAMM00055950 DAP001275 Approved Drug Phytonadione
CFAMM00055650 DNC003523 Investigative Drug 1,2-NAPHTHOQUINONE
CFAMM00055885 DNC005474 Investigative Drug 1-(3,4-Dimethyl-phenyl)-2-phenyl-ethane-1,2-dione
CFAMM00055602 DNC007842 Investigative Drug 1-(4-octylphenyl)prop-2-en-1-one
CFAMM00055551 DNC003276 Investigative Drug 2,3-DIMETHYL-1,4-NAPHTHOQUINONE
CFAMM00055601 DNC007843 Investigative Drug 1-(4-heptylphenyl)prop-2-en-1-one
CFAMM00056001 DNC009075 Investigative Drug ANTHRAQUINONE
CFAMM00055912 DNC000027 Investigative Drug 1,4-Naphthoquinone
CFAMM00055962 DNC005431 Investigative Drug 1-Phenyl-propane-1,2-dione
CFAMM00055883 DNC005473 Investigative Drug 1,2-Di-p-tolyl-ethane-1,2-dione
CFAMM00055806 DNC007853 Investigative Drug phenanthrene-9,10-dione
CFAMM00055758 DNC006427 Investigative Drug 3-isopropyl-4-phenylnaphthalene-1,2-dione
CFAMM00056088 DNC007839 Investigative Drug (E)-1-(4-heptylphenyl)but-2-en-1-one
CFAMM00056000 DNC009076 Investigative Drug 5,6,7,8-tetrahydroanthracene-1,4-dione
CFAMM00056066 DNC006799 Investigative Drug 1-(3,4-dihydronaphthalen-1-yl)ethanone
CFAMM00055805 DNC007855 Investigative Drug 11,12-dihydro-dibenzo[a,e]cyclooctene-5,6-dione
CFAMM00055882 DNC005472 Investigative Drug 1-Phenyl-2-p-tolyl-ethane-1,2-dione
CFAMM00055757 DNC006426 Investigative Drug 3-isopropylnaphthalene-1,2-dione
CFAMM00055590 DNC003886 Investigative Drug MK-11
CFAMM00055916 DNC011723 Investigative Drug 2-(2-Methyl-benzoyl)-cyclohexane-1,3-dione
CFAMM00056072 DNC008096 Investigative Drug MK-9

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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