CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Abelson tyrosine-protein kinase 2 inhibitor thiazole derivative Dasatinib Family
No. of Seeds 19 No. of Other Members 50
Family Centroid CFAMM00000384 Functional Category Approved Drug
Superfamily Abelson tyrosine-protein kinase 2 inhibitor thiazole derivative Dasatinib Superfamily
Class Class 4

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Adenosine receptor A1 Ligand 4-nitro-n-(4-phenyl-thiazol-2-yl)... 2 38
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 9 inhibitor AG... 3 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 1 1
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Tyrosine-protein kinase Lck inhibitor benzothiazole analog 11 ... 7 13
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MSE family 18 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MPV family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HLHQ family 2 0


External ID

Functional Category

Molecule Name

CFAMM00000384 DAP000004 Approved Drug Dasatinib
CFAMM00000389 CHEMBL385698 Bioactive N-(2-chloro-6-methylphenyl)-2-[[6-(2-hydroxyethylamino)pyridin-2-yl]amino]-1,3-thiazole-5-carboxamide
CFAMM00000417 CHEMBL217039 Bioactive AGN-PC-00FWO2
CFAMM00000374 CHEMBL424906 Bioactive AGN-PC-006WCQ
CFAMM00000402 CHEMBL188478 Bioactive AGN-PC-03HL9X
CFAMM00000381 CHEMBL189649 Bioactive AGN-PC-00A38J
CFAMM00000394 CHEMBL431986 Bioactive AGN-PC-074MRZ
CFAMM00000387 CHEMBL214617 Bioactive AGN-PC-009O7R
CFAMM00000386 CHEMBL364623 Bioactive N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
CFAMM00000414 CHEMBL189675 Bioactive AGN-PC-03HLCE
CFAMM00000379 CHEMBL240158 Bioactive AGN-PC-046YCH
CFAMM00000406 CHEMBL189776 Bioactive AGN-PC-03HL7Z
CFAMM00000377 CHEMBL273250 Bioactive AGN-PC-005YJ3
CFAMM00000391 CHEMBL384545 Bioactive AGN-PC-03HL9T
CFAMM00000419 CHEMBL360810 Bioactive AGN-PC-03HLEI
CFAMM00000427 CHEMBL186568 Bioactive AGN-PC-03HLH5
CFAMM00000369 CHEMBL365505 Bioactive AGN-PC-03HLA4
CFAMM00000411 CHEMBL386118 Bioactive AGN-PC-008HV5
CFAMM00000426 CHEMBL216240 Bioactive AGN-PC-005H5Y

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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