CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor Progesterone Family
No. of Seeds 20 No. of Other Members 283
Family Centroid CFAMM00056516 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor Progesterone Superfamily
Class Class 325

Cousin Family NamesSeedsMembers
Corticosteroid-binding globulin Inhibitor Rimexolone Family 6 138
Androgen receptor ligand anabolic androgenic steroid Testoster... 8 198
Progesterone receptor ligand steroidal progestin Etonogestrel ... 8 31
Progesterone receptor ligand steroidal progestin Medroxyproges... 6 20
Glucocorticoid receptor ligand corticosteroid Prednisone Family 2 1
Mineralocorticoid receptor ligand steroid progestogen analog D... 3 240
Dienogest family 1 3
Hydroxyprogesterone family 4 37
Trimegestone family 7 25
Oestrogen receptor Ligand Gestrinone Family 2 2
Nuclear receptor subfamily 1 group I member 2 Ligand Pregnenol... 1 1
CAMP-phosphodiesterase Inhibitor S(-)enantiomer Of 3-(3-hydrox... 1 0
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type... 2 43
C-C chemokine receptor type 5 Ligand Variecolin Family 1 0
Aromatase inhibitor RU54115 Analog 57 family 2 14
Aromatase inhibitor (10R,13S)-13-methyl-10-(oxiran-2-yl)-2,6,7... 1 0
Aromatase inhibitor [(6R)-10,13-dimethyl-17-oxo-1,2,3,6,7,8,9,... 4 17
Bile acid receptor ligand lupeone family 1 24
Bile acid receptor and Prolyl endopeptidase ligand beta-Elemon... 1 4
Aromatase inhibitor [(8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo... 1 4
Nitric oxide synthase, inducible inhibitor Zhankuic Acid A Met... 1 0
Aromatase inhibitor (16S)-16-bromo-10,13-dimethyl-1,2,3,6,7,8,... 2 0
Prenol Lipids Metabolite (R)-Carvotanacetone Family 11 30
Steroids and Steroid Derivatives Metabolite 5Alpha-cholesta-8-... 1 2
Prenol Lipids Metabolite Acolamone Family 1 4
Prenol Lipids Metabolite (E)-5,8-Megastigmadien-4-one Family 4 8
Prenol Lipids Metabolite (-)-trans-Isopulegone Family 5 6
Prenol Lipids Metabolite 3-Caren-5-one Family 1 0
Prenol Lipids Metabolite Solavetivone Family 3 0
Prenol Lipids Metabolite (+)-4,11-Eudesmadien-3-one Family 1 1
Prenol Lipids Metabolite Dihydro-alpha-ionone Family 2 0
Prenol Lipids Metabolite beta-Atlantone Family 2 1
Prenol Lipids Metabolite Vulgarone A Family 1 2
Prenol Lipids Metabolite Tyromycic acid Family 1 0


External ID

Functional Category

Molecule Name

CFAMM00056691 DAP001205 Approved Drug Dydrogesterone
CFAMM00056486 DNAP001571 Approved Drug Promegestone
CFAMM00056455 DAP000625 Approved Drug Exemestane
CFAMM00056516 DAP000549 Approved Drug Progesterone
CFAMM00056658 DAP001389 Approved Drug Guggulsterone
CFAMM00056563 CHEMBL98685 Bioactive (10S,13S)-10-ethenyl-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056413 CHEMBL282673 Bioactive (6R)-10,13-dimethyl-6-propyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056599 CHEMBL25588 Bioactive (6S)-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056382 CHEMBL25695 Bioactive (6S)-10,13-dimethyl-6-propyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056746 CHEMBL25059 Bioactive (6R)-6-ethyl-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056560 CHEMBL24037 Bioactive (6R)-6-butyl-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056683 CHEMBL24021 Bioactive (6S)-6-ethyl-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056469 CHEMBL24410 Bioactive (6S)-6-ethenyl-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056692 CHEMBL421018 Bioactive (10R,13S)-2,2,10,13-tetramethyl-1,6,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,17-dione
CFAMM00056396 CHEMBL319108 Bioactive (10R,13S)-10-ethyl-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CFAMM00056732 DNC004284 Investigative Drug ANDROSTENEDONE
CFAMM00056626 DNC009933 Investigative Drug NSC-93358
CFAMM00056462 DNC003121 Investigative Drug 4-ANDROSTENE-3-17-DIONE
CFAMM00056646 DNC003725 Investigative Drug MDL-18962
CFAMM00056742 DNC008078 Investigative Drug E-GUGGULSTERONE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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