CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD401
Family Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Lovastatin Family
No. of Seeds 13 No. of Other Members 79
Family Centroid CFAMM00056865 Functional Category Approved Drug with Natural Product
Superfamily 3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Lovastatin Superfamily
Class Class 326

Cousin Family NamesSeedsMembers
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (3R)... 2 4
3,11-dihydroxy-2,4,6,8,10,12-hexamethyl-9-oxotetradec-6-enoate... 8 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00056866 DAP000552 Approved Drug Simvastatin
CFAMM00056865 DAP000551 Approved Drug Lovastatin
CFAMM00056864 DAP000550 Approved Drug Pravastatin
CFAMM00056879 CHEMBL311800 Bioactive [(1S,3R,7S,8S,8aR)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] but-3-enoate
CFAMM00056826 CHEMBL79583 Bioactive SureCN8291088
CFAMM00056893 CHEMBL355287 Bioactive [(1S,3R,7S,8S)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylpropanoate
CFAMM00056841 CHEMBL435270 Bioactive [(1S,3R,7S,8S)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylpropanoate
CFAMM00056858 CHEMBL167159 Bioactive [(1S,3R,7S,8S)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2R)-2-methylbutanoate
CFAMM00056911 CHEMBL2364554 Bioactive [(1S,3R,7S,8S)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate;sodium
CFAMM00056819 CHEMBL352791 Bioactive [(1S,3R,7S,8S)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 3-methylbutanoate
CFAMM00056903 CHEMBL168768 Bioactive [(1S,3R,7S,8S)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] pentanoate
CFAMM00056811 CHEMBL168884 Bioactive [(1S,3R,7S,8S)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 3-methylbut-3-enoate
CFAMM00056835 DNC003318 Investigative Drug Mevastatin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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