CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD403
Family Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Fluvastatin Family
No. of Seeds 6 No. of Other Members 53
Family Centroid CFAMM00056975 Functional Category Approved Drug with Human Metabolite
Superfamily 3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Fluvastatin Superfamily
Class Class 327

Cousin Family NamesSeedsMembers
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Ator... 3 24
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Stat... 5 21
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor PF-3... 6 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (3S)... 3 3
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor AC1O... 18 10
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 3 3
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor Sure... 2 6
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (3R,... 3 3
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor Sure... 2 5
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor Sure... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00056975 DAP000554 Approved Drug Fluvastatin
CFAMM00056972 CHEMBL1161646 Bioactive (E,3R,5S)-7-[3-(4-fluorophenyl)-2-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00056983 CHEMBL1161649 Bioactive (E,3R,5S)-7-[2-(4-fluorophenyl)-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyhept-6-enoic acid
CFAMM00056953 CHEMBL1078 Bioactive fluvastatin
CFAMM00056996 DCL000933 Clinical Trial Drug Pitavastatin
CFAMM00056978 DNC013453 Investigative Drug PITAVASTATIN CALCIUM

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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