CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD409
Family Name Acetylcholinesterase Inhibitor Donepezil Family
No. of Seeds 23 No. of Other Members 242
Family Centroid CFAMM00057982 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Acetylcholinesterase Inhibitor Donepezil Superfamily
Class Class 333

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Muscarinic acetylcholine receptor Ligand Mebeverine Family 2 27
Hydrastine family 6 115
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Ivabradine family 1 11
Elagolix family 43 98
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Endothelin-1 receptor Ligand PD156707 Family 41 211
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 18 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase Inhibitor AP-2238 Family 2 109
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Acetylcholinesterase Inhibitor Taspine Family 1 0
DNA topoisomerase 1 Inhibitor NSC-341622 Family 1 1
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
D(2) dopamine receptor Ligand Epidepride Family 31 66
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 8
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OX family 2 0
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Histamine H1 receptor ligand Ahr 5333 family 1 6
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Histamine H3 receptor ligand SureCN2784769 family 12 2
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Sigma non-opioid intracellular receptor 1 and Vesicular acetyl... 3 7
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Cocaine esterase and Liver carboxylesterase 1 inhibitor 2-Chlo... 1 5
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 2 5
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Acetylcholinesterase inhibitor (5S)-5-[4-(5,6-dimethoxy-3-oxo-... 1 3
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 2 20
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Acetylcholinesterase and Butyrylcholinesterase inhibitor 2-[4-... 3 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Aromatase inhibitor AGN-PC-07ZE7R family 1 1
Sterol 26-hydroxylase, mitochondrial and 1,25-dihydroxyvitamin... 1 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075EXY... 3 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-00... 5 14
Sodium/hydrogen exchanger 1 inhibitor 4-(1-acetylpiperidin-4-y... 1 1
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] and Retinal deh... 1 1
Multidrug resistance protein 1 inhibitor 1-[4-[(2R)-2-hydroxy-... 1 0
Reverse transcriptase/RNaseH inhibitor Thiazoloisoindol-5-one ... 1 2
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
Putative NP ZINC20113153 Family 20 0
NP (e)-4-methoxy-6,6-dimethyl-5-(2-oxo-4-(2,6,6-trimethylcyclo... 131 0
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
Putative NP ZINC08791780 Family 3 0
NP (7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepin-4-yl)... 4 2
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0
Putative NP ZINC02424496 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00057982 DAP000560 Approved Drug Donepezil
CFAMM00057854 CHEMBL2043045 Bioactive (2Z)-2-benzylidene-5-methoxy-6-(2-piperidin-1-ylethoxy)-3H-inden-1-one
CFAMM00057968 CHEMBL170946 Bioactive SureCN4201141
CFAMM00057776 CHEMBL1083065 Bioactive AGN-PC-07ZG2D
CFAMM00057986 CHEMBL2448118 Bioactive KS-1051
CFAMM00057845 CHEMBL353468 Bioactive SureCN14491049
CFAMM00057921 CHEMBL435071 Bioactive SureCN221177
CFAMM00057952 CHEMBL110268 Bioactive 2-[5-[ethyl-[(2-methoxyphenyl)methyl]amino]pentyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
CFAMM00057967 CHEMBL2093912 Bioactive (2S)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
CFAMM00057844 CHEMBL107316 Bioactive CHEBI:53292
CFAMM00057868 CHEMBL538069 Bioactive AGN-PC-001SLT
CFAMM00057746 CHEMBL322392 Bioactive SureCN9248134
CFAMM00057972 CHEMBL1083982 Bioactive AGN-PC-07ZFSQ
CFAMM00058039 CHEMBL355160 Bioactive SureCN2138710
CFAMM00058047 CHEMBL544860 Bioactive AGN-PC-001SLU
CFAMM00057902 CHEMBL544161 Bioactive AGN-PC-001SKA
CFAMM00057940 CHEMBL108726 Bioactive CHEBI:53290
CFAMM00058019 CHEMBL123014 Bioactive 2-(1-benzylpiperidin-4-yl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
CFAMM00057767 CHEMBL145446 Bioactive SureCN220807
CFAMM00057846 CHEMBL1678 Bioactive Donepezil hydrochloride
CFAMM00057976 CHEMBL540607 Bioactive AGN-PC-001SLZ
CFAMM00057802 CHEMBL557839 Bioactive AGN-PC-001SLW
CFAMM00058002 DNC001028 Investigative Drug N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi)

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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