CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD412
Family Name Acetylcholinesterase Inhibitor Neostigmine Family
No. of Seeds 4 No. of Other Members 76
Family Centroid CFAMM00058321 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Acetylcholinesterase Inhibitor Neostigmine Superfamily
Class Class 336

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Inosine-5'-monophosphate dehydrogenase Inhibitor VX-148 Family 2 3
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Angiotensin-converting enzyme inhibitor AGN-PC-076HUS family 2 3
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Acetylcholinesterase and Cholinesterase inhibitor [3-hydroxy-5... 2 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-087BON family 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand (5Z,8... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00058326 DAP000894 Approved Drug Demecarium bromide
CFAMM00058321 DAP000563 Approved Drug Neostigmine
CFAMM00058366 CHEMBL54126 Bioactive neostigmine bromide
CFAMM00058346 DNC011053 Investigative Drug 3-(dimethylamino)phenyl phenylcarbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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