CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD419
Family Name Alpha-1B adrenergic receptor ligand Morpholine derivative Phendimetrazine Family
No. of Seeds 4 No. of Other Members 152
Family Centroid CFAMM00059053 Functional Category Approved Drug with Natural Product
Superfamily Biogenic amine receptor Diphenhydramine Phendimetrazine Diphenylpyraline Superfamily
Class Class 231

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Histamine H1 receptor Ligand Clemastine Family 5 76
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Substance-P receptor Ligand Ezlopitant Family 10 207
Pitolisant family 4 24
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Choline kinase alpha Inhibitor Hemicholinium-3 Family 4 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Substance-P receptor Ligand L-733060 Family 19 71
Substance-P receptor Ligand 3,6-diphenyl-1-oxa-7-aza-spiro[4.5... 1 25
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-P receptor Ligand SCH-388714 Family 26 8
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 7
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 1 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-076TWX... 8 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4
Substance-P receptor ligand N-[(3S,6S)-6-[[(1R)-1-[3,5-bis(tri... 1 0
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
Acetylcholinesterase inhibitor (2S)-2-(4-chlorophenyl)-4,4-dim... 1 0
Sigma non-opioid intracellular receptor 1 ligand N-benzyl-2-[(... 1 5
Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0
Sodium-dependent serotonin transporter and Substance-P recepto... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 9 1
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 1 2
Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trif... 9 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand SureCN8415737 family 3 4
Sigma non-opioid intracellular receptor 1 ligand SureCN7425449... 2 0
Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
C-C chemokine receptor type 5 ligand AC1LAKN8 family 4 5
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Substance-P receptor ligand AGN-PC-02K8GG family 1 1
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Substance-P receptor and Potassium voltage-gated channel subfa... 2 0
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-phenylmethoxy-... 1 7
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Substance-P receptor ligand SureCN8912140 family 2 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0
Histamine H1 receptor and 5-hydroxytryptamine receptor 2A liga... 1 0
Extracellular calcium-sensing receptor ligand SureCN4609584 fa... 7 8
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 2 1
Cathepsin K and Cathepsin L1 inhibitor 3-(phenylmethoxymethyl)... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (4aR,... 1 0
Membrane primary amine oxidase inhibitor 1-[2-(3-fluorophenyl)... 5 0
Membrane primary amine oxidase and Amine oxidase [flavin-conta... 2 0
(4R,5S)-4-methyl-5-phenyl-1,3-oxazolidin-2-one NP (4r,5s)-4-me... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00059053 DAP000574 Approved Drug Phendimetrazine
CFAMM00059011 DAP000860 Approved Drug Phenmetrazine
CFAMM00059111 DNC010974 Investigative Drug (2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol
CFAMM00058994 DNC011817 Investigative Drug 2-Phenyl-3-(1-phenyl-ethoxy)-piperidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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