CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Angiotensin-converting enzyme Inhibitor Captopril Family
No. of Seeds 13 No. of Other Members 27
Family Centroid CFAMM00061012 Functional Category Approved Drug
Superfamily Angiotensin-converting enzyme Inhibitor Captopril Superfamily
Class Class 350

Cousin Family NamesSeedsMembers
Glutamine receptor Ligand L-alanyl-l-glutamine Family 3 101
Hepatitis C Vaccine family 1 5
Farnesyltransferase beta subunit, putative and Protein farnesy... 3 29
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Alp... 4 18
Sodium/glucose cotransporter 1 Inhibitor Qcpac Family 4 7
Angiotensin-converting enzyme inhibitor (8S)-7-[(2S)-2-methyl-... 1 3
Beta-lactamase and DNA-(apurinic or apyrimidinic site) lyase i... 1 8
Peptides Metabolite Valyl-Hydroxyproline Family 1 1


External ID

Functional Category

Molecule Name

CFAMM00061012 DAP000589 Approved Drug Captopril
CFAMM00060981 CHEMBL276104 Bioactive (2S)-4,4-dimethoxy-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
CFAMM00060994 CHEMBL347388 Bioactive (2S)-1-[(2R)-3,3,3-trifluoro-2-(sulfanylmethyl)propanoyl]pyrrolidine-2-carboxylic acid
CFAMM00061005 CHEMBL311525 Bioactive (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-5-oxopyrrolidine-2-carboxylic acid
CFAMM00060971 CHEMBL110375 Bioactive AGN-PC-041GBK
CFAMM00061019 CHEMBL277951 Bioactive (2S,4S)-4-methylsulfanyl-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
CFAMM00061011 CHEMBL68068 Bioactive (1S,3S,5S)-2-[(2S)-2-methyl-3-sulfanylpropanoyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
CFAMM00060998 CHEMBL279763 Bioactive (2S,4S)-4-methyl-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
CFAMM00061003 CHEMBL66217 Bioactive (1R,3S,5R)-2-[(2S)-2-methyl-3-sulfanylpropanoyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
CFAMM00061018 CHEMBL417994 Bioactive (2S,4S)-4-hydroxy-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
CFAMM00060997 CHEMBL16138 Bioactive (2S,4S)-4-methoxy-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
CFAMM00060996 CHEMBL16139 Bioactive (8S)-7-[(2S)-2-methyl-3-sulfanylpropanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
CFAMM00060995 CHEMBL161170 Bioactive 1-[(2R)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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