CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD432
Family Name Beta adrenergic receptor Ligand Dipivefrin Family
No. of Seeds 3 No. of Other Members 55
Family Centroid CFAMM00061078 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Beta adrenergic receptor Ligand Dipivefrin Superfamily
Class Class 332

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Renin Inhibitor Aliskiren Family 28 107
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Zucapsacin family 7 177
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Extracellular calcium-sensing receptor Ligand Ronacaleret Family 2 9
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
Substance-P receptor Ligand DA-5018 Family 14 73
D(3) dopamine receptor Ligand U-99194A Family 7 33
Vernakalant family 1 1
Ivabradine family 1 11
Ceramide glucosyltransferase Inhibitor Eliglustat Tartrate Family 3 2
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Vasopeptidase Inhibitor Fasidotril Family 3 7
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Tubulin beta chain Inhibitor 6-ile-ustiloxin Family 4 3
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 5 2
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
Extracellular calcium-sensing receptor and Sodium-dependent no... 2 2
Transient receptor potential cation channel subfamily V member... 3 18
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 0
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 5
Membrane primary amine oxidase inhibitor 2-[amino(methyl)amino... 2 0
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 4 3
Calpain-1 catalytic subunit inhibitor (2E)-2-[(3,4-dihydroxyph... 4 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 3
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
Putative NP ZINC14589285 Family 2 1
3-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)amino... 3 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC04029538 Family 3 0
NP (1s,5r,z)-2-(1-((4-methoxybenzyl)amino)ethylidene)-6,6-dime... 4 0
Putative NP ZINC02099241 Family 12 0
3-benzazepin-2-one NP 7,8-dimethoxy-1h-benzo[d]azepin-2(3h)-on... 2 0
Putative NP ZINC04287792 Family 2 0
(2S)-1-[2-[4-(8-methoxy-2-oxochromen-3-yl)phenoxy]acetyl]pyrro... 1 0
Putative NP ZINC00050501 Family 6 4
Putative NP ZINC08453899 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00061078 DAP000593 Approved Drug Dipivefrin
CFAMM00061084 DNAP001566 Approved Drug Ibopamine hci
CFAMM00061069 CHEMBL31638 Bioactive methyl 3-[4-[3-[2-(3,4-dimethoxyphenyl)ethylamino]-2-hydroxypropoxy]phenyl]propanoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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