CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Calcineurin inhibitor macrolactam Pimecrolimus Family
No. of Seeds 24 No. of Other Members 1
Family Centroid CFAMM00061145 Functional Category Approved Drug
Superfamily Serine/threonine-protein kinase inhibitor macrolide,Calcineurin inhibitor macrolactam Superfamily
Class Class 128

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase mTOR and Serine/threonine-prot... 14 34


External ID

Functional Category

Molecule Name

CFAMM00061145 DAP000594 Approved Drug Pimecrolimus
CFAMM00061143 CHEMBL51516 Bioactive CHEMBL51516
CFAMM00061156 CHEMBL68027 Bioactive CHEMBL68027
CFAMM00061149 CHEMBL56278 Bioactive [(E)-3-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-methylprop-2-enyl] (2S)-1-[2-[(2R,3R,5S,6R)-2-hydroxy-5-methoxy-6-(methoxymethyl)-3-methyloxan-2-yl]-2-oxoacetyl]piperidine-2-carboxylate
CFAMM00061155 CHEMBL48863 Bioactive CHEMBL48863
CFAMM00061148 CHEMBL303852 Bioactive CHEMBL303852
CFAMM00061141 CHEMBL405819 Bioactive CHEMBL405819
CFAMM00061154 CHEMBL71458 Bioactive SureCN14389791
CFAMM00061147 CHEMBL369579 Bioactive CHEMBL369579
CFAMM00061140 CHEMBL355620 Bioactive CHEMBL355620
CFAMM00061153 CHEMBL2062149 Bioactive CHEMBL2062149
CFAMM00061146 CHEMBL366891 Bioactive CHEMBL366891
CFAMM00061159 CHEMBL52035 Bioactive CHEMBL52035
CFAMM00061139 CHEMBL276623 Bioactive [(1E,3S)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-methylocta-1,7-dien-3-yl] (2S)-1-[2-[(2R,3R,5S,6R)-2-hydroxy-5-methoxy-6-(methoxymethyl)-3-methyloxan-2-yl]-2-oxoacetyl]piperidine-2-carboxylate
CFAMM00061152 CHEMBL299146 Bioactive CHEMBL299146
CFAMM00061158 CHEMBL2052020 Bioactive CHEMBL2052020
CFAMM00061151 CHEMBL170655 Bioactive CHEMBL170655
CFAMM00061144 CHEMBL170544 Bioactive CHEMBL170544
CFAMM00061157 CHEMBL405104 Bioactive CHEMBL405104
CFAMM00061150 CHEMBL70822 Bioactive CHEMBL70822
CFAMM00061160 DNC000852 Investigative Drug L-685,818

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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