CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Catechol O-methyltransferase Inhibitor Tolcapone Family
No. of Seeds 7 No. of Other Members 19
Family Centroid CFAMM00061312 Functional Category Approved Drug
Superfamily Catechol O-methyltransferase Inhibitor Tolcapone Superfamily
Class Class 359

Cousin Family NamesSeedsMembers
Catechol O-methyltransferase Inhibitor Entacapone Family 1 4
Catechol O-methyltransferase Inhibitor Bia Family 1 0
Catechol O-methyltransferase Inhibitor 5,6-dihydroxy-7-nitro-2... 1 0
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 1 2
Tyrosinase Inhibitor 4'-amino-4-hydroxychalcone Family 1 4
Arachidonate 5-lipoxygenase inhibitor (E)-3-(3,4-dihydroxyphen... 2 1
Prelamin-A/C inhibitor CHEMBL1322186 family 1 7


External ID

Functional Category

Molecule Name

CFAMM00061312 DAP000607 Approved Drug Tolcapone
CFAMM00061335 CHEMBL169926 Bioactive SureCN7281446
CFAMM00061329 DNC005894 Investigative Drug 6,7-dihydroxy-8-nitro-1-tetralone
CFAMM00061336 DNC007257 Investigative Drug 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenoxyethanone
CFAMM00061328 DNC000313 Investigative Drug BIA 3-202
CFAMM00061315 DNC005893 Investigative Drug 1-(3,4-dihydroxy-2-nitrophenyl)-2-phenylethanone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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